Chemical Name: 2-[((1,1'-Biphenyl)-4-ylamino)carbonyl]benzoic acid
Biological ActivityPotently induces differentiation of human mesenchymal stem cells into chondrocytes (EC50 = 100 nM). Reduces disease severity in a mouse model of osteoarthritis; displays protective effects against osteoarthritic stimuli in mature chondrocytes in vitro.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
A stem cell-based approach to cartilage repair.
Johnson et al.
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