Chemical Name: 2-[((1,1'-Biphenyl)-4-ylamino)carbonyl]benzoic acid
Biological ActivityPotently induces differentiation of human mesenchymal stem cells into chondrocytes (EC50 = 100 nM). Reduces disease severity in a mouse model of osteoarthritis; displays protective effects against osteoarthritic stimuli in mature chondrocytes in vitro.
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A stem cell-based approach to cartilage repair.
Johnson et al.
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Added to culture medium on days 1-3 at 10 µM to induced chondrogenic differentiation in an immortalized hBMSC cell line. After 7 days there was increased sulfated GAG production compared to basic controls and increased DNA yield compared to cells cultured in traditional chondrogenic differentiation medium.