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Kartogenin

4513 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4513/10
4513/50

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Kartogenin | CAS No. 4727-31-5 | Compounds for Stem Cell Differentiation
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Description: Potently induces chondrogenesis in MSCs

Chemical Name: 2-[((1,1'-Biphenyl)-4-ylamino)carbonyl]benzoic acid

Purity: ≥98%

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Biological Activity

Kartogenin potently induces differentiation of human mesenchymal stem cells into chondrocytes (EC50 = 100 nM). Reduces disease severity in a mouse model of osteoarthritis; displays protective effects against osteoarthritic stimuli in mature chondrocytes in vitro.

Technical Data

M.Wt:
317.34
Formula:
C20H15NO3
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
4727-31-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. A stem cell-based approach to cartilage repair.
    Johnson et al.
    Science, 2012;336:717

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