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Kartogenin

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Kartogenin | CAS No. 4727-31-5 | Compounds for Stem Cell Differentiation
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Description: Potently induces chondrogenesis in MSCs

Chemical Name: 2-[((1,1'-Biphenyl)-4-ylamino)carbonyl]benzoic acid

Purity: ≥98%

Product Details
Reviews (1)
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Kartogenin is a potently induces differentiation of human mesenchymal stem cells into chondrocytes (EC50 = 100 nM). Reduces disease severity in a mouse model of osteoarthritis; displays protective effects against osteoarthritic stimuli in mature chondrocytes in vitro.

Technical Data

M.Wt:
317.34
Formula:
C20H15NO3
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
4727-31-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. A stem cell-based approach to cartilage repair.
    Johnson et al.
    Science, 2012;336:717

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Chondrogenic differentiation of human bone marrow stromal cells
By Nicola Foster on 08/28/2020
Application: Species: Human

Added to culture medium on days 1-3 at 10 µM to induced chondrogenic differentiation in an immortalized hBMSC cell line. After 7 days there was increased sulfated GAG production compared to basic controls and increased DNA yield compared to cells cultured in traditional chondrogenic differentiation medium.

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