KB SRC 4

Catalog # Availability Size / Price Qty
4660/10
4660/50
Cat.No. 4660 - KB SRC 4 | C32H23ClN8 | CAS No. 1380088-03-8
1 Image
Description: Potent and selective c-Src inhibitor

Chemical Name: 1-[3-[1-([1,1'-Biphenyl]-3-ylmethyl)-1H-1,2,3-triazol-5-yl]phenyl]-3-(4-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Product Details
Citations (2)
Reviews

Biological Activity

Potent and selective c-Src inhibitor (Ki = 44 nM); does not inhibit c-Abl at concentrations up to 125 μM. Selective between Src family members (Kd values are 86, 160, 240, 720, 3200, 4400, and >40,000 nM for c-Src, Lck, Fgr, Yes, Lyn, Hck and Fyn respectively). Significantly inhibits cell growth in 4T1 mammary carcinoma tumor cells.

Technical Data

Formula:
C32H23ClN8
Solubility:
Soluble to 20 mM in DMSO
Storage:
Store the unopened product at 2 - 8 °C. Do not use past expiration date.
CAS No:
1380088-03-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

Background References

  1. Development of a highly selective c-Src kinase inhibitor.
    Brandvold et al.
    ACS Chem.Biol., 2012;7:1393

Product Datasheets

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Citations for KB SRC 4

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