KB SRC 4
Chemical Name: 1-[3-[1-([1,1'-Biphenyl]-3-ylmethyl)-1H-1,2,3-triazol-5-yl]phenyl]-3-(4-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Biological ActivityPotent and selective c-Src inhibitor (Ki = 44 nM); does not inhibit c-Abl at concentrations up to 125 μM. Selective between Src family members (Kd values are 86, 160, 240, 720, 3200, 4400, and >40,000 nM for c-Src, Lck, Fgr, Yes, Lyn, Hck and Fyn respectively). Significantly inhibits cell growth in 4T1 mammary carcinoma tumor cells.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Development of a highly selective c-Src kinase inhibitor.
Brandvold et al.
ACS Chem.Biol., 2012;7:1393
Citations for KB SRC 4
The citations listed below are publications that use Tocris products. Selected citations for KB SRC 4 include:
2 Citations: Showing 1 - 2
Lamellipodin promotes invasive 3D cancer cell migration via regulated interactions with Ena/VASP and SCAR/WAVE.
Authors: Carmona Et al.
An endoplasmic reticulum stress-initiated sphingolipid metabolite, ceramide-1-phosphate, regulates epithelial innate immunity by stimulating β-defensin production.
Authors: Kim Et al.
Mol Cell Biol 2014;34:4368
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
Reviews for KB SRC 4
There are currently no reviews for this product. Be the first to review KB SRC 4 and earn rewards!
Have you used KB SRC 4?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image