KF 38789
Chemical Name: 3-[7-(2,4-Dimethoxyphenyl)-2,3,6,7-tetrahydro-1,4-thiazepin-5-yl]-4-hydroxy-6-methyl-2H-pyran-2-one
Purity: ≥97%
Biological Activity
KF 38789 is a selective inhibitor of P-selectin-mediated cell adhesion (IC50 = 1.97 μM) that displays no effects on L-selectin- and E-selectin-mediated adhesion. Blocks P-selectin-mediated binding in vitro and leukocyte accumulation in vivo.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Dissecting cellular processes using small molecules: identification of colchicine-like, taxol-like and other small moleculaes that perturb mitosis.
Haggerty et al.
Chem.Biol., 2000;7:275 -
Inhibition of P-selectin specific cell adhesion by a low molecular weight, non-carbohydrate compound, KF38779.
Ohta et al.
Inflamm.Res., 2001;50:544 -
Synthesis and biological evaluation of quinoline salicylic acids as P-selectin antagonists.
Kaila et al.
J.Med.Chem., 2007;50:21
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Citations for KF 38789
The citations listed below are publications that use Tocris products. Selected citations for KF 38789 include:
2 Citations: Showing 1 - 2
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Sialyl Lewisx-P-selectin cascade mediates tumor-mesothelial adhesion in ascitic fluid shear flow.
Authors: Li Et al.
Nat Commun 2019;10:2406
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Deletion of junctional adhesion molecule A from platelets increases early-stage neointima formation after wire injury in hyperlipidemic mice.
Authors: Zhao Et al.
J Cell Mol Med 2017;21:1523
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We worked to determine the inhibitory effects of KF 38789 on P-selectin-mediated cell adhesion.KF 38789 shows selective inhibition and works ideally.
