Catalog Number: 2748
Chemical Name: 3-[7-(2,4-Dimethoxyphenyl)-2,3,6,7-tetrahydro-1,4-thiazepin-5-yl]-4-hydroxy-6-methyl-2H-pyran-2-one
Biological Activity
Selective inhibitor of P-selectin-mediated cell adhesion (IC50 = 1.97 μM) that displays no effects on L-selectin- and E-selectin-mediated adhesion. Blocks P-selectin-mediated binding in vitro and leukocyte accumulation in vivo.
Technical Data
  • M.Wt:
    375.44
  • Formula:
    C19H21NO5S
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >97%
  • Storage:
    Desiccate at +4°C
  • CAS No:
    257292-29-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Dissecting cellular processes using small molecules: identification of colchicine-like, taxol-like and other small moleculaes that perturb mitosis.
    Haggerty et al.
    Chem.Biol., 2000;7:275
  2. Inhibition of P-selectin specific cell adhesion by a low molecular weight, non-carbohydrate compound, KF38779.
    Ohta et al.
    Inflamm.Res., 2001;50:544
  3. Synthesis and biological evaluation of quinoline salicylic acids as P-selectin antagonists.
    Kaila et al.
    J.Med.Chem., 2007;50:21

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