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KF 38789

2748 2 Citations 1 Review Datasheet / COA / SDS
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KF 38789 | CAS No. 257292-29-8 | Cell Adhesion Inhibitors
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Description: Selective inhibitor of P-selectin-mediated cell adhesion

Chemical Name: 3-[7-(2,4-Dimethoxyphenyl)-2,3,6,7-tetrahydro-1,4-thiazepin-5-yl]-4-hydroxy-6-methyl-2H-pyran-2-one

Purity: ≥97%

Product Details
Citations (2)
Supplemental Products
Reviews (1)
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Selective inhibitor of P-selectin-mediated cell adhesion (IC50 = 1.97 μM) that displays no effects on L-selectin- and E-selectin-mediated adhesion. Blocks P-selectin-mediated binding in vitro and leukocyte accumulation in vivo.

Technical Data

M.Wt:
375.44
Formula:
C19H21NO5S
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥97%
Storage:
Desiccate at +4°C
CAS No:
257292-29-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for KF 38789

The citations listed below are publications that use Tocris products. Selected citations for KF 38789 include:

2 Citations: Showing 1 - 2

  1. Sialyl Lewisx-P-selectin cascade mediates tumor-mesothelial adhesion in ascitic fluid shear flow.
    Authors: Li Et al.
    Nat Commun  2019;10:2406
  2. Deletion of junctional adhesion molecule A from platelets increases early-stage neointima formation after wire injury in hyperlipidemic mice.
    Authors: Zhao Et al.
    J Cell Mol Med  2017;21:1523

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VersaClone cDNA Plasmids

Human P-Selectin/CD62P (NP_002996) VersaClone cDNA

RDC1881

Mouse P-Selectin/CD62P (NP_035477) VersaClone cDNA

RDC2338

Reviews for KF 38789

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We worked to determine the inhibitory effects of KF 38789 on P-selectin-mediated cell adhesion
By Meghan Bradshaw on 02/20/2019
Application: Species: Human

We worked to determine the inhibitory effects of KF 38789 on P-selectin-mediated cell adhesion.KF 38789 shows selective inhibition and works ideally.

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