KF 38789
Chemical Name: 3-[7-(2,4-Dimethoxyphenyl)-2,3,6,7-tetrahydro-1,4-thiazepin-5-yl]-4-hydroxy-6-methyl-2H-pyran-2-one
Purity: ≥97%
Biological Activity
KF 38789 is a selective inhibitor of P-selectin-mediated cell adhesion (IC50 = 1.97 μM) that displays no effects on L-selectin- and E-selectin-mediated adhesion. KF 38789 blocks P-selectin-mediated binding in vitro and leukocyte accumulation in vivo.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
Dissecting cellular processes using small molecules: identification of colchicine-like, taxol-like and other small moleculaes that perturb mitosis.
Haggerty et al.
Chem.Biol., 2000;7:275 -
Inhibition of P-selectin specific cell adhesion by a low molecular weight, non-carbohydrate compound, KF38779.
Ohta et al.
Inflamm.Res., 2001;50:544 -
Synthesis and biological evaluation of quinoline salicylic acids as P-selectin antagonists.
Kaila et al.
J.Med.Chem., 2007;50:21
Product Datasheets
Reconstitution Calculator
Molarity Calculator
FAQs
No product specific FAQs exist for this product, however you may
View all Small Molecule FAQsReviews for KF 38789
Average Rating: 5 (Based on 1 Review)
Have you used KF 38789?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Filter by:
We worked to determine the inhibitory effects of KF 38789 on P-selectin-mediated cell adhesion.KF 38789 shows selective inhibition and works ideally.
