Selective inhibitor of P-selectin-mediated cell adhesion (IC50
= 1.97 μ
M) that displays no effects on L-selectin- and E-selectin-mediated adhesion. Blocks P-selectin-mediated binding in vitro
and leukocyte accumulation in vivo
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All Tocris products are intended for laboratory research use only.
Dissecting cellular processes using small molecules: identification of colchicine-like, taxol-like and other small moleculaes that perturb mitosis.
Haggerty et al.
Inhibition of P-selectin specific cell adhesion by a low molecular weight, non-carbohydrate compound, KF38779.
Ohta et al.
Synthesis and biological evaluation of quinoline salicylic acids as P-selectin antagonists.
Kaila et al.