Chemical Name: 3-[7-(2,4-Dimethoxyphenyl)-2,3,6,7-tetrahydro-1,4-thiazepin-5-yl]-4-hydroxy-6-methyl-2H-pyran-2-one
Biological ActivityKF 38789 is a selective inhibitor of P-selectin-mediated cell adhesion (IC50 = 1.97 μM) that displays no effects on L-selectin- and E-selectin-mediated adhesion. KF 38789 blocks P-selectin-mediated binding in vitro and leukocyte accumulation in vivo.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Dissecting cellular processes using small molecules: identification of colchicine-like, taxol-like and other small moleculaes that perturb mitosis.
Haggerty et al.
Inhibition of P-selectin specific cell adhesion by a low molecular weight, non-carbohydrate compound, KF38779.
Ohta et al.
Synthesis and biological evaluation of quinoline salicylic acids as P-selectin antagonists.
Kaila et al.
Citations for KF 38789
The citations listed below are publications that use Tocris products. Selected citations for KF 38789 include:
3 Citations: Showing 1 - 3
Microengineered perfusable 3D-bioprinted glioblastoma model for in vivo mimicry of tumor microenvironment
Authors: Neufeld Et al.
Sci Adv 2021;7:eabi9119
Sialyl Lewisx-P-selectin cascade mediates tumor-mesothelial adhesion in ascitic fluid shear flow.
Authors: Li Et al.
Nat Commun 2019;10:2406
Deletion of junctional adhesion molecule A from platelets increases early-stage neointima formation after wire injury in hyperlipidemic mice.
Authors: Zhao Et al.
J Cell Mol Med 2017;21:1523
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VersaClone cDNA Plasmids
Reviews for KF 38789
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We worked to determine the inhibitory effects of KF 38789 on P-selectin-mediated cell adhesion.KF 38789 shows selective inhibition and works ideally.