Chemical Name: N-(2,4-Difluorophenyl)-N'-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]-2-fluorophenyl]urea
Biological ActivityKi 8751 is a potent, selective inhibitor of VEGFR-2 tyrosine kinase (IC50 = 0.9 nM). Displays some inhibitory activity towards c-Kit, PDGFRα and FGFR-2 (IC50 values range from 40 to 170 nM) but is highly selective over other receptor tyrosine kinases (IC50 > 10000 nM for FGFR-2, EGFR and HGFR). Inhibits VEGF-stimulated proliferation of human umbilical vein endothelial cells (HUVEC) and inhibits tumor growth in vivo; antiangiogenic.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Citations for Ki 8751
The citations listed below are publications that use Tocris products. Selected citations for Ki 8751 include:
3 Citations: Showing 1 - 3
Positive Feedback Defines the Timing, Magnitude, and Robustness of Angiogenesis.
Authors: Page Et al.
Cell Rep 2019;27:3139
Regulation of breast cancer induced bone disease by cancer-specific IKKβ.
Authors: Marino Et al.
Investigation of a novel molecular descriptor for the lead optimization of 4-aminoquinazolines as vascular endothelial growth factor receptor-2 inhibitors: application for quantitative structure-activity relationship analysis in lead optimization.
Authors: Kawakami Et al.
J Neurosci 2011;21:1371
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