Catalog Number: 3207
Chemical Name: (5R,6R,7S,8R,8aS)-Hexahydro-6,7,8-trihydroxy-5-(hydroxymethyl)-imidazo[1,2-a]pyridine-2,3-dione
Biological Activity
Inhibitor of class I α-mannosidases that inhibits glycoprotein processing. Inhibits human endoplasmic reticulum α-1,2-mannosidase I and Golgi Class I mannosidases IA, IB and IC with Ki values of 130 and 23 nM respectively.
Technical Data
  • M.Wt:
    232.19
  • Formula:
    C8H12N2O6
  • Solubility:
    Soluble to 10 mM in water with sonication
  • Storage:
    Store at -20°C
  • CAS No:
    109944-15-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. A practical synthesis of kifunensine analogues as inhibitors of endoplasmic reticulum α-Mannosidase I.
    Hering et al.
    J.Org.Chem., 2005;70:9892
  2. Kifunensine, a potent inhibitor of the glycoprotein processing mannosidase I.
    Elbein et al.
    J.Biol.Chem., 1990;265:1559

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