Kifunensine

Tocris Bioscience | Catalog # 3207

Inhibitor of class I α-mannosidases
Tocris Bioscience

Key Product Details

Description

Inhibitor of class I α-mannosidases
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Product Description

Kifunensine is an inhibitor of class I α-mannosidases that inhibits glycoprotein processing. Kifunensine inhibits human endoplasmic reticulum α-1,2-mannosidase I and Golgi Class I mannosidases IA, IB and IC with Ki values of 130 and 23 nM respectively. Kifunensine disrupts normal trafficking of the GLUT1 transporter, leading to decreased glucose uptake in human renal epithelial cells. Kifunensine impaires tumour cell aggregation in human ovarian cancer cells in vitro.

Product Specifications for Kifunensine

Molecular Weight

232.19

Formula

C8H12N2O6

Storage

Store at -20°C

Chemical Name

(5R,6R,7S,8R,8aS)-Hexahydro-6,7,8-trihydroxy-5-(hydroxymethyl)-imidazo[1,2-a]pyridine-2,3-dione

CAS Number

109944-15-2

PubChem ID

130611

InChI Key

OIURYJWYVIAOCW-PQMKYFCFSA-N

SMILES

O[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)N2[C@@]([H])1NC(C2=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 1.16 5 with sonication

Preparing Stock Solutions for Kifunensine

The following data is based on the product molecular weight 232.19.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.05 mM 86.14 mL 430.68 mL 861.36 mL
0.25 mM 17.23 mL 86.14 mL 172.27 mL
0.5 mM 8.61 mL 43.07 mL 86.14 mL
2.5 mM 1.72 mL 8.61 mL 17.23 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 37 publications citing the usage of this product.

Product Documents for Kifunensine

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Kifunensine

For research use only

Customer Reviews for Kifunensine (1)

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  • works as expected
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: HEK293
    Verified Customer | Posted 10/23/2018
    time added post transfect did not matter
    1 uM/mL culture for transient transfection in KEK293 cells
    Kifunensine 3207

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