Kifunensine

Catalog # Availability Size / Price Qty
3207/1
Kifunensine | CAS No. 109944-15-2 | Glycosylase Inhibitors
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Description: Inhibitor of class I α-mannosidases

Chemical Name: (5R,6R,7S,8R,8aS)-Hexahydro-6,7,8-trihydroxy-5-(hydroxymethyl)-imidazo[1,2-a]pyridine-2,3-dione

Product Details
Citations (1)
Reviews (1)

Biological Activity

Inhibitor of class I α-mannosidases that inhibits glycoprotein processing. Inhibits human endoplasmic reticulum α-1,2-mannosidase I and Golgi Class I mannosidases IA, IB and IC with Ki values of 130 and 23 nM respectively.

Technical Data

M.Wt:
232.19
Formula:
C8H12N2O6
Solubility:
Soluble to 5 mM in water with sonication
Storage:
Store at -20°C
CAS No:
109944-15-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. A practical synthesis of kifunensine analogues as inhibitors of endoplasmic reticulum α-Mannosidase I.
    Hering et al.
    J.Org.Chem., 2005;70:9892
  2. Kifunensine, a potent inhibitor of the glycoprotein processing mannosidase I.
    Elbein et al.
    J.Biol.Chem., 1990;265:1559

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Citation for Kifunensine

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works as expected
By Anonymous on 10/23/2018
Application: Species: Human

1 uM/mL culture for transient transfection in KEK293 cells


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