Chemical Name: (5R,6R,7S,8R,8aS)-Hexahydro-6,7,8-trihydroxy-5-(hydroxymethyl)-imidazo[1,2-a]pyridine-2,3-dione
Biological ActivityInhibitor of class I α-mannosidases that inhibits glycoprotein processing. Inhibits human endoplasmic reticulum α-1,2-mannosidase I and Golgi Class I mannosidases IA, IB and IC with Ki values of 130 and 23 nM respectively.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
A practical synthesis of kifunensine analogues as inhibitors of endoplasmic reticulum α-Mannosidase I.
Hering et al.
Kifunensine, a potent inhibitor of the glycoprotein processing mannosidase I.
Elbein et al.
Citation for Kifunensine
The citations listed below are publications that use Tocris products. Selected citations for Kifunensine include:
1 Citation: Showing 1 - 1
Lentiviral transduction of mammalian cells for fast, scalable and high-level production of soluble and membrane proteins.
Authors: Elegheert Et al.
Nat Protoc 2018;13:2991
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1 uM/mL culture for transient transfection in KEK293 cells