High affinity Myc inhibitor (Kd
= 6.5 nM). Disrupts Myc-Max interaction. Inhibits Myc-dependent cancer cell line proliferation in vitro
. Inhibits growth of MDA-MB-231 breast cancer cell xenografts in mice. Brain penetrant.
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Inhibitor of MYC identified in a Kröhnke pyridine library.
Hart et al.