KL 465

Tocris Bioscience | Catalog # 8854

MAGE-A3 Degrader (PROTAC®)
Tocris Bioscience

Key Product Details

Description

MAGE-A3 Degrader (PROTAC®)
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Product Description

KL 465 is a MAGE-A3 Degrader (PROTAC®) (DC50 = 2 μM; Dmax = 60%). MAGE-A3 degradation with KL 465 decreases cancer cell viability and is VHL dependent.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Product Specifications for KL 465

Molecular Weight

1021.20

Formula

C56H60N8O9S

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

(2S,4R)-N-(2-(2-(2-(2-((4-(Furan-2-carbonyl)piperazin-1-yl)methyl)-4-(1H-indazol-4-yl)phenoxy)ethoxy)ethoxy)-4-(4-methylthiazol-5-yl)benzyl)-4-hydroxy-1-((S)-3-methyl-2-(1-oxoisoindolin-2-yl)butanoyl)pyrrolidine-2-carboxamide

CAS Number

3057446-82-6

InChI Key

MQOTXOOWIOCPNH-IYCLWVRSSA-N

SMILES

O=C(C1=CC=CO1)N2CCN(CC2)CC3=CC(C4=CC=CC5=C4C=NN5)=CC=C3OCCOCCOC6=CC(C7=C(N=CS7)C)=CC=C6CNC([C@@H]8C[C@H](CN8C([C@H](C(C)C)N9CC%10=C(C9=O)C=CC=C%10)=O)O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 51.06 50

Preparing Stock Solutions for KL 465

The following data is based on the product molecular weight 1021.20.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 1.96 mL 9.79 mL 19.58 mL
2.5 mM 0.39 mL 1.96 mL 3.92 mL
5 mM 0.20 mL 0.98 mL 1.96 mL
25 mM 0.04 mL 0.20 mL 0.39 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for KL 465

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for KL 465

For research use only

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