Potent DDHD2 inhibitor (IC50
= 1.3 nM). Selective for DDHD2 over 40 other serine hydrolases, but does exhibit cross-reactivity with ABHD6. Active in vivo
. Increases brain triacylglycerol levels in mice.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Sold under license from The Scripps Research Institute
The hereditary spastic paraplegia-related enzyme DDHD2 is a principal brain triglyceride lipase.
Inloes et al.