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Potent CD38 inhibitor; active in vivo
Potent flap endonuclease 1 (FEN1) inhibitor; induces DNA damage response
Selective neutral sphingomyelin phosphodiesterase (N-SMase) inhibitor
Potent and reversible SARM1 NAD hydrolase inhibitor
O-GlcNAcase and β-hexosaminidase inhibitor
Potent and selective inhibitor of serine hydrolase KIAA1363 (AADACL1)
Potent and selective N-SMase2 inhibitor; brain penetrant
α/β-hydrolase domain 6 (ABHD6) inhibitor; antiepileptic
Selective PFKFB3 inhibitor
Selective and reversible lysophospholipase 2 (LYPLA2) inhibitor
Selective and reversible lysophospholipase 1 (LYPLA1) inhibitor
Potent O-GlcNAcase inhibitor
Potent and irreversible α/β-hydrolase domain 6 (ABHD6) inhibitor
Potent N-acylethanolamine acid amidase (NAAA) inhibitor; NAAA activity-based protein profiling (ABPP) probe
Potent N-acylethanolamine acid amidase inhibitor; NAAA activity-based protein profiling (ABPP) probe
HIF-prolyl hydroxylase-2 (PHD2) inhibitor; antioxidant
Potent dCTP pyrophosphatase 1 inhibitor
Potent and selective MTH1 inhibitor
Potent, selective and irreversible α/β-hydrolase domain 6 (ABHD6) inhibitor
Potent soluble epoxide hydrolase (sEH) Inhibitor; anti-inflammatory and antinociceptive
Potent influenza virus neuraminidase inhibitor
Influenza virus neuraminidase inhibitor; antiviral prodrug
Potent steroid sulfatase inhibitor; also inhibits carbonic anhydrase II
HIF-PH inhibitor; erythropoietic