Hydrolase Inhibitors: Products

Urease inhibitor

Arginase inhibitor

Potent CD38 inhibitor; active in vivo

Potent flap endonuclease 1 (FEN1) inhibitor; induces DNA damage response

Selective neutral sphingomyelin phosphodiesterase (N-SMase) inhibitor

Potent and reversible SARM1 NAD hydrolase inhibitor

O-GlcNAcase and β-hexosaminidase inhibitor

Potent and selective inhibitor of serine hydrolase KIAA1363 (AADACL1)

Potent MTH1 inhibitor

Potent NUDT5 inhibitor

Potent and selective N-SMase2 inhibitor; brain penetrant

Potent ABHD6 inhibitor

PFKFB3 inhibitor

α/β-hydrolase domain 6 (ABHD6) inhibitor; antiepileptic

Selective PFKFB3 inhibitor

Selective and reversible lysophospholipase 2 (LYPLA2) inhibitor

Selective and reversible lysophospholipase 1 (LYPLA1) inhibitor

Potent O-GlcNAcase inhibitor

Potent and irreversible α/β-hydrolase domain 6 (ABHD6) inhibitor

Potent N-acylethanolamine acid amidase (NAAA) inhibitor; NAAA activity-based protein profiling (ABPP) probe

Potent N-acylethanolamine acid amidase inhibitor; NAAA activity-based protein profiling (ABPP) probe

HIF-prolyl hydroxylase-2 (PHD2) inhibitor; antioxidant

MTH1 inhibitor

Potent dCTP pyrophosphatase 1 inhibitor

Potent and selective MTH1 inhibitor

Potent, selective and irreversible α/β-hydrolase domain 6 (ABHD6) inhibitor

Potent soluble epoxide hydrolase (sEH) Inhibitor; anti-inflammatory and antinociceptive

nSMase2 inhibitor

Potent influenza virus neuraminidase inhibitor

Influenza virus neuraminidase inhibitor; antiviral prodrug

Potent steroid sulfatase inhibitor; also inhibits carbonic anhydrase II

HIF-PH inhibitor; erythropoietic