Highly selective and potent monoacylglycerol lipase (MAGL) inhibitor. Exhibits potent inhibition of human, mouse and rat MAGL (IC50
values are 5.9, 15 and 43 nM, respectively). Exhibits no detectable inhibition of FAAH (IC50
> 50000 nM). Potently and selectively blocks hydrolysis of 2-arachidonoylglycerol (2-AG) in mice (IC50
= 2.5 nM and >50 μ
M for 2-AG and AEA respectively).
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Sold under license from The Scripps Research Institute
Discrimination between two endocannabinoids.
Ueda et al.
Highly selective inhibitors of monoacylglycerol lipase bearing a reactive group that is bioisosteric with endocannabinoid substrates.
Chang et al.
The citations listed below are publications that use Tocris products. Selected citations for KML 29 include:
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