Catalog Number: 4872
Chemical Name: 4-[Bis(1,3-benzodioxol-5-yl)hydroxymethyl]-1-piperidinecarboxylic acid 2,2,2-trifluoro-1-(trifluoromethyl)ethyl ester
Biological Activity
Highly selective and potent monoacylglycerol lipase (MAGL) inhibitor. Exhibits potent inhibition of human, mouse and rat MAGL (IC50 values are 5.9, 15 and 43 nM, respectively). Exhibits no detectable inhibition of FAAH (IC50 > 50000 nM). Potently and selectively blocks hydrolysis of 2-arachidonoylglycerol (2-AG) in mice (IC50 = 2.5 nM and >50 μM for 2-AG and AEA respectively).
Technical Data
  • M.Wt:
    549.42
  • Formula:
    C24H21F6NO7
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    1380424-42-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold under license from The Scripps Research Institute
Background References
  1. Discrimination between two endocannabinoids.
    Ueda et al.
    Chem.Biol., 2012;19:545
  2. Highly selective inhibitors of monoacylglycerol lipase bearing a reactive group that is bioisosteric with endocannabinoid substrates.
    Chang et al.
    Chem.Biol., 2012;19:579
Citations:

The citations listed below are publications that use Tocris products. Selected citations for KML 29 include:

1 Citations: Showing 1 - 1

  1. Emotional arousal state influences the ability of amygdalar endocannabinoid signaling to modulate anxiety.
    Authors: Morena Et al.
    Neuropharmacology 2016;111:59

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