KRCA 0008

   
Product Datasheet
Catalog Number:5098
Chemical Name:1,1'-[(5-Chloro-2,4-pyrimidinediyl)bis[imino(3-methoxy-4,1-phenylene)-4,1-piperazinediyl]]bisethanone
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Biological Activity
Potent Ack1 and anaplastic lymphoma kinase (ALK) dual inhibitor (IC50 values are 4 and 12 nM respectively). Inhibits lung cancer H3122 cell proliferation (IC50 = 80 nM). Attenuates H3122 cell xenograft tumor growth in mice. Orally bioavailable.
Technical Data
  • M.Wt:
    609.12
  • Formula:
    C30H37ClN8O4
  • Solubility:
    Soluble to 100 mM in 1eq. HCl and to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
    >99
  • Storage:
    Store at -20°C
  • CAS No:
    1472795-20-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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