Catalog Number: 5480
Chemical Name: N2-1H-Indazol-5-yl-N6-methyl-3-nitro-2,6-pyridinediamine
Biological Activity
Heat shock factor (HSF) inhibitor (IC50 = 1.2 μM). Increases apoptosis in cancer cells treated with the HSP90 inhibitors Geldanamycin (Cat. No. 1368) and 17-AAG (Cat. No. 1515). Blocks downstream induction of HSP27 and HSP70. Inhibits tumor growth in vivo.
Technical Data
  • M.Wt:
    284.27
  • Formula:
    C13H12N6O2
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at -20°C
  • CAS No:
    342639-96-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. KRIBB11 inhibits HSP70 synthesis through inhibition of heat shock factor 1 function by impairing the recruitment of positive transcription elongation factor b to the hsp70 promoter.
    Yoon YJ, Kim JA, Shin KD et al.
    J Biol Chem
  2. Heat shock factor 1 confers resistance to Hsp90 inhibitors through p62/SQSTM1 expression and promotion of autophagic flux.
    Samarasinghe et al.
    Biochem. Pharmacol., 2014;87:445

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