Chemical Name: N2-1H-Indazol-5-yl-N6-methyl-3-nitro-2,6-pyridinediamine
Biological ActivityKRIBB11 is a heat shock factor (HSF) inhibitor (IC50 = 1.2 μM). Increases apoptosis in cancer cells treated with the HSP90 inhibitors Geldanamycin (Cat. No. 1368) and 17-AAG (Cat. No. 1515). Blocks downstream induction of HSP27 and HSP70. Inhibits tumor growth in vivo.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
KRIBB11 inhibits HSP70 synthesis through inhibition of heat shock factor 1 function by impairing the recruitment of positive transcription elongation factor b to the hsp70 promoter.
Yoon YJ, Kim JA, Shin KD et al.
J Biol Chem
Heat shock factor 1 confers resistance to Hsp90 inhibitors through p62/SQSTM1 expression and promotion of autophagic flux.
Samarasinghe et al.
Biochem. Pharmacol., 2014;87:445
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