KT 5720

Tocris Bioscience | Catalog # 1288

Selective protein kinase A inhibitor
Tocris Bioscience

Key Product Details

Description

Selective protein kinase A inhibitor
View all Protein Kinase A Inhibitors »

Product Description

KT 5720 is a potent, selective inhibitor of protein kinase A (Ki = 60 nM). Has no effect on PKG or PKC (Ki > 2 μM). Reversibly arrests human skin fibroblasts in the G1 phase.

Product Specifications for KT 5720

Molecular Weight

537.61

Formula

C32H31N3O5

Storage

Store at -20°C

Purity

≥97% (HPLC)

Chemical Name

(9R,10S,12S)-2,3,9,10,11,12-Hexahydro-10-hydroxy-9-methyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid, hexyl ester

CAS Number

108068-98-0

PubChem ID

9850141

InChI Key

ZHEHVZXPFVXKEY-MWOZDUBJSA-N

SMILES

O[C@@]1(C(OCCCCCC)=O)C[C@@H]2O[C@]1(N3C4=CC=CC=C4C5=C3C6=C(C7=C5CNC7=O)C8=CC=CC=C8N26)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 26.88 50

Preparing Stock Solutions for KT 5720

The following data is based on the product molecular weight 537.61.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 3.72 mL 18.60 mL 37.20 mL
2.5 mM 0.74 mL 3.72 mL 7.44 mL
5 mM 0.37 mL 1.86 mL 3.72 mL
25 mM 0.07 mL 0.37 mL 0.74 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 247 publications citing the usage of this product.

Product Documents for KT 5720

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for KT 5720

For research use only

Customer Reviews for KT 5720 (2)

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  • Pancreatic cancer signaling testing
    Name: MARINA KOUTSIOUMPA
    Species: Human
    Assay Type: In Vitro
    Verified Customer | Posted 12/26/2023
    Pancreatic cancer cells were pretreated for 2 hours with KT 5720, triethylammonium salt followed by conventional chemotherapeutics. Selective Inhibition of Protein Kinase A mediated the signal transduction pathways triggered by the chemotherapeutics.
  • Excellent PKA inhibitor
    Name: Gaurang Trivedi
    Species: Mouse
    Assay Type: In Vitro
    Cell Line/Tissue: Stem Cells
    Verified Customer | Posted 09/28/2019
    It is an excellent inhibitor for PKA.

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