Chemical Name: (9R,10S,12S)-2,3,9,10,11,12-Hexahydro-10-hydroxy-9-methyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid, hexyl ester
Biological ActivityKT 5720 is a potent, selective inhibitor of protein kinase A (Ki = 60 nM). Has no effect on PKG or PKC (Ki > 2 μM). Reversibly arrests human skin fibroblasts in the G1 phase.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
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Effects of selective inhibition of protein kinase C, cyclic AMP-dependent protein kinase, and Ca(2+)-calmodulin-dependent protein kinase on neurite development in cultured rat hippocampal neurons.
Cabell et al.
Int.J.Dev. Neurosci., 1993;11:357
Multiple kinase arrest points in the G1 phase of nontransformed mammalian cells are absent in transformed cells.
Gadbois et al.
K-252 compounds, novel and potent inhibitors of protein kinase C and cyclic nucleotide-dependent protein kinases.
Kase et al.
Citations for KT 5720
The citations listed below are publications that use Tocris products. Selected citations for KT 5720 include:
28 Citations: Showing 1 - 10
Pimavanserin, a 5HT 2A receptor inverse agonist, rapidly suppresses Aβ production and related pathology in a mouse model of Alzheimer's disease.
Authors: Yuede Et al.
Imiquimod suppresses respiratory syncytial virus (RSV) replication via PKA pathway and reduces RSV induced-inflammation and viral load in mice lungs
Authors: Salinar Et al.
Antiviral Res 2020;179
The readily-releasable pool dynamically regulates multivesicular release.
Authors: Vaden Et al.
Protein kinase A activation inhibits DUX4 gene expression in myotubes from patients with facioscapulohumeral muscular dystrophy.
Authors: Cruz Et al.
J Biol Chem 2018;293:11837
Mutant GNAS drives pancreatic tumourigenesis by inducing PKA-mediated SIK suppression and reprogramming lipid metabolism.
Authors: Patra Et al.
Nat Cell Biol 2018;20:811
Enriched environment enhances β-adrenergic signaling to prevent microglia inflammation by amyloid-β.
Authors: Xu Et al.
EMBO Mol Med 2018;10
Endocannabinoid dynamics gate spike-timing dependent depression and potentiation.
Authors: Cui Et al.
Elevated levels of calcitonin gene-related peptide in upper spinal cord promotes sensitization of primary trigeminal nociceptive neurons
Authors: Cornelison Et al.
Progesterone receptor membrane component-1 regulates hepcidin biosynthesis.
Authors: Li Et al.
J Clin Invest 2016;126:389
Potentiation of Schaffer-Collateral CA1 Synaptic Transmission by eEF2K and p38 MAPK Mediated Mechanisms.
Authors: Weng Et al.
Front Cell Neurosci 2016;10:247
Protection against β-amyloid-induced synaptic and memory impairments via altering β-amyloid assembly by bis(heptyl)-cognitin.
Authors: Chang Et al.
Sci Rep 2015;5:10256
Pioglitazone restores IGFBP-3 levels through DNA PK in retinal endothelial cells cultured in hyperglycemic conditions.
Authors: Thakran Et al.
PLoS One 2015;56:177
Phosphorylation of ezrin on Thr567 is required for the synergistic activation of cell spreading by EPAC1 and protein kinase A in HEK293T cells.
Authors: Parnell Et al.
Invest Ophthalmol Vis Sci 2015;1853:1749
The Effects of the Endocannabinoids Anandamide and 2-Arachidonoylglycerol on Human Osteoblast Proliferation and Differentiation.
Authors: Smith Et al.
PLoS One 2015;10:e0136546
Glucagon Increases Beating Rate but Not Contractility in Rat Right Atrium. Comparison with isoprote.
Authors: Merino Et al.
Br J Pharmacol 2015;10:e0132884
Steady-state modulation of voltage-gated K+ channels in rat arterial smooth muscle by cyclic AMP-dependent protein kinase and protein phosphatase 2B.
Authors: Brignell Et al.
J Neurosci 2015;10:e0121285
Central vagal afferent endings mediate reduction of food intake by melanocortin-3/4 receptor agonist.
Authors: Campos Et al.
J Neurosci 2014;34:12636
Loss of long-term depression in the insular cortex after tail amputation in adult mice.
Authors: Liu and Zhuo
Mol Pain 2014;10:1
The role of mislocalized phototransduction in photoreceptor cell death of retinitis pigmentosa.
Authors: Nakao Et al.
PLoS One 2012;7:e32472
The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP.
Authors: Lee Et al.
DArgic modulation of ganglion-cell photoreceptors in rat.
Authors: Hook Et al.
Biochim Biophys Acta 2012;35:507
OX2R activation induces PKC-mediated ERK and CREB phosphorylation.
Authors: Guo and Feng
Exp Cell Res 2012;318:2004
β1-Adrenergic receptors activate two distinct signaling pathways in striatal neurons.
Authors: Meitzen Et al.
J Neurochem 2011;116:984
Prostatic acid phosphatase reduces thermal sensitivity and chronic pain sensitization by depleting phosphatidylinositol 4,5-bisphosphate.
Authors: Sowa Et al.
J Neurosci 2010;30:10282
A crucial role for cAMP and protein kinase A in D1 DA receptor regulated intracellular calcium transients.
Authors: Dai Et al.
Altered Ca(2+) handling by ryanodine receptor and Na(+)-Ca(2+) exchange in the heart from ovariectomized rats: role of protein kinase A.
Authors: Kravtsov Et al.
Am J Physiol Cell Physiol 2007;292:C1625
Regulation of nuclear factor κB in the hippocampus by group I metabotropic glutamate receptors.
Authors: O'Riordan Et al.
PLoS One 2006;26:4870
TRPV1 receptors mediate particulate matter-induced apoptosis.
Authors: Agopyan Et al.
Am J Physiol Lung Cell Mol Physiol 2004;286:L563
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