Catalog Number: 1288
Chemical Name: (9R,10S,12S)-2,3,9,10,11,12-Hexahydro-10-hydroxy-9-methyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid, hexyl ester
Biological Activity
Potent, selective inhibitor of protein kinase A (Ki = 60 nM). Has no effect on PKG or PKC (Ki > 2 μM). Reversibly arrests human skin fibroblasts in the G1 phase.
Technical Data
  • M.Wt:
    537.61
  • Formula:
    C32H31N3O5
  • Solubility:
    Soluble to 50 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Desiccate at -20°C
  • CAS No:
    108068-98-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Effects of selective inhibition of protein kinase C, cyclic AMP-dependent protein kinase, and Ca(2+)-calmodulin-dependent protein kinase on neurite development in cultured rat hippocampal neurons.
    Cabell et al.
    Int.J.Dev. Neurosci., 1993;11:357
  2. Multiple kinase arrest points in the G1 phase of nontransformed mammalian cells are absent in transformed cells.
    Gadbois et al.
    Proc.Natl.Acad.Sci.U.S.A., 1992;89:8626
  3. K-252 compounds, novel and potent inhibitors of protein kinase C and cyclic nucleotide-dependent protein kinases.
    Kase et al.
    Biochem.Biophys.Res.Commun., 1987;142:436
Citations:

The citations listed below are publications that use Tocris products. Selected citations for KT 5720 include:

13 Citations: Showing 1 - 10
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  1. Elevated levels of calcitonin gene-related peptide in upper spinal cord promotes sensitization of primary trigeminal nociceptive neurons
    Authors: Cornelison Et al.
    Neuroscience 2016;339:491
  2. Pioglitazone restores IGFBP-3 levels through DNA PK in retinal endothelial cells cultured in hyperglycemic conditions.
    Authors: Thakran Et al.
    PLoS One 2015;56:177
  3. Phosphorylation of ezrin on Thr567 is required for the synergistic activation of cell spreading by EPAC1 and protein kinase A in HEK293T cells.
    Authors: Parnell Et al.
    Invest Ophthalmol Vis Sci 2015;1853:1749
  4. The Effects of the Endocannabinoids Anandamide and 2-Arachidonoylglycerol on Human Osteoblast Proliferation and Differentiation.
    Authors: Smith Et al.
    PLoS One 2015;10:e0136546
  5. Glucagon Increases Beating Rate but Not Contractility in Rat Right Atrium. Comparison with Isoproterenol.
    Authors: Merino Et al.
    Br J Pharmacol 2015;10:e0132884
  6. Steady-state modulation of voltage-gated K+ channels in rat arterial smooth muscle by cyclic AMP-dependent protein kinase and protein phosphatase 2B.
    Authors: Brignell Et al.
    J Neurosci 2015;10:e0121285
  7. The role of mislocalized phototransduction in photoreceptor cell death of retinitis pigmentosa.
    Authors: Nakao Et al.
    PLoS One 2012;7:e32472
  8. The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP.
    Authors: Lee Et al.
    Nature 2012;492:123
  9. Dopaminergic modulation of ganglion-cell photoreceptors in rat.
    Authors: Hook Et al.
    Biochim Biophys Acta 2012;35:507
  10. OX2R activation induces PKC-mediated ERK and CREB phosphorylation.
    Authors: Guo and Feng
    Exp Cell Res 2012;318:2004
  11. β1-Adrenergic receptors activate two distinct signaling pathways in striatal neurons.
    Authors: Meitzen Et al.
    J Neurochem 2011;116:984
  12. Prostatic acid phosphatase reduces thermal sensitivity and chronic pain sensitization by depleting phosphatidylinositol 4,5-bisphosphate.
    Authors: Sowa Et al.
    J Neurosci 2010;30:10282
  13. Regulation of nuclear factor κB in the hippocampus by group I metabotropic glutamate receptors.
    Authors: O'Riordan Et al.
    PLoS One 2006;26:4870
Expand to show all 13 Citations

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