KYA 1797K

Key Product Details

Product Description

KYA 1797K is a Wnt/β-catenin signaling inhibitor (IC₅₀ = 0.75 μM). Increases binding affinity of β-catenin for axin, GSK-3β and β-TrCP. Promotes formation of the destruction complex, activation of GSK-3β and phosphorylation of β-catenin and K-Ras, leading to their degradation via the ubiquitin/proteasome system. Reduces levels of β-catenin and K-Ras and inhibits growth of colorectal cancer (CRC) cells in vitro and in mouse xenograft models.

Product Specifications for KYA 1797K

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for KYA 1797K

The following data is based on the product molecular weight 442.50.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.05 mM	45.20 mL	225.99 mL	451.98 mL
0.25 mM	9.04 mL	45.20 mL	90.40 mL
0.5 mM	4.52 mL	22.60 mL	45.20 mL
2.5 mM	0.90 mL	4.52 mL	9.04 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Park A Ras destabilizer KYA1797K overcomes the resistance of EGFR tyrosine kinase inhibitor in KRAS-mutated non-small cell lung cancer. Sci.Rep. 2019 PMID: 30679620
• Cha Small-molecule binding of the axin RGS domain promotes β-catenin and Ras degradation. Nat.Chem.Biol. 2016 PMID: 27294323

Product Documents for KYA 1797K