KYA 1797K

Catalog # Availability Size / Price Qty
7002/5
7002/25
KYA 1797K | CAS No. 1956356-56-1 | beta-Catenin Compounds
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Description: Wnt/β-catenin signaling inhibitor

Chemical Name: (5Z)-5-[[5-(4-Nitrophenyl)-2-furanyl]methylene]-4-oxo-2-thioxo-3-thiazolidinepropanoic acid potassium salt

Purity: ≥98%

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Biological Activity

Wnt/β-catenin signaling inhibitor (IC50 = 0.75 μM). Increases binding affinity of β-catenin for axin, GSK-3β and β-TrCP. Promotes formation of the destruction complex, activation of GSK-3β and phosphorylation of β-catenin and K-Ras, leading to their degradation via the ubiquitin/proteasome system. Reduces levels of β-catenin and K-Ras and inhibits growth of colorectal cancer (CRC) cells in vitro and in mouse xenograft models.

Technical Data

M.Wt:
442.5
Formula:
C17H11KN2O6S2
Solubility:
Soluble to 5 mM in DMSO with gentle warming
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1956356-56-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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