KYL

Name: KYL
Brand: Tocris Bioscience
SKU: 5290
Price: 208 USD
Availability: InStock

Tocris Bioscience | Catalog # 5290

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Citations (1)

Product Documents

EphA4 kinase inhibitor; neuroprotective

Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

EphA4 kinase inhibitor; neuroprotective

View all Eph Receptor Inhibitors »

Product Description

KYL is an EphA4 receptor tyrosine kinase inhibitor (K_d = 0.8 μM); inhibits EphA4-EphrinA5 interactions (IC₅₀ = 6.34 μM). Prevents AβO induced synaptic damage, dendritic spine loss and prevents the blocking of LTP in hippocampal CA3-CA1 transmissions. Exhibits a long half life in cell culture media (8 and 12 hours in PC3 and C2C12 media respectively). Neuroprotective.

Product Specifications for KYL

Molecular Weight

1465.75

Formula

C₇₄H₁₀₈N₁₄O₁₇

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

676657-00-4

PubChem ID

91691122

InChI Key

FZNPYIAZMDBRLC-RKNDTPCJSA-N

SMILES

[H]N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 2mg/ml in water

Calculators

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Background References

References are publications that support the biological activity of the product.

Vargas EphA4 activation of c-Abl mediates synaptic loss and LTP blockade caused by amyloid-β oligomers. PLoS One. 2014 PMID: 24658113
Lamberto Distinctive binding of three antagonistic peptides to the ephrin-binding pocket of the EphA4 receptor. Biochem. J. 2012 PMID: 22489865

Product Documents for KYL

Certificate of Analysis

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Product Specific Notices for KYL

For research use only

Citations for KYL

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