Biological ActivityEphA4 receptor tyrosine kinase inhibitor (Kd = 0.8 μM); inhibits EphA4-EphrinA5 interactions (IC50 = 6.34 μM). Prevents AβO induced synaptic damage, dendritic spine loss and prevents the blocking of LTP in hippocampal CA3-CA1 transmissions. Exhibits a long half life in cell culture media (8 and 12 hours in PC3 and C2C12 media respectively). Neuroprotective.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Distinctive binding of three antagonistic peptides to the ephrin-binding pocket of the EphA4 receptor.
Lamberto et al.
Biochem. J., 2012;445:47
EphA4 activation of c-Abl mediates synaptic loss and LTP blockade caused by amyloid-β oligomers.
Vargas et al.
PLoS One., 2014;9:e92309
Citation for KYL
The citations listed below are publications that use Tocris products. Selected citations for KYL include:
1 Citation: Showing 1 - 1
EphA4-ADAM10 Interplay Patterns the Cochlear Sensory Epithelium through Local Disruption of Adherens Junctions.
Authors: Defourny Et al.
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