KYP 2047 New
Chemical Name: (2S)-1-[[(2S)-1-(1-Oxo-4-phenylbutyl)-2-pyrrolidinyl]carbonyl]-2-pyrrolidinecarbonitrile
Biological ActivityHigh affinity prolyl oligopeptidase (POP) inhibitor (Ki = 0.023 nM). Clears α-synuclein aggregates induced by oxidative stress in neuronal cells. Inhibits the formation of AcSDKP from its precursor 43-mer thymosin β4 (Tβ4). Induces angiogenesis via POP inhibition. Anti-angiogenic and neuroprotective. Brain penetrant.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Binding kinetics and duration of in vivo action of novel prolyl oligopeptidase inhibitors.
Venäläinen et al.
A prolyl oligopeptidase inhibitor, KYP-2047, reduces alpha-synuclein protein levels and aggregates in cellular and animal models of Parkinson's disease.
Myöhänen et al.
Brain pharmacokinetics of two prolyl oligopeptidase inhibitors, JTP-4819 and KYP-2047, in the rat.
Jalkanen et al.
Basic Clin.Pharmacol.Toxicol., 2011;109:443
Prolyl oligopeptidase induces angiogenesis both in vitro and in vivo in a novel regulatory manner.
Myöhänen et al.
Inhibition of alpha-synuclein aggregation by multifunctional Da agonists assessed by a novel in vitro assay and an in vivo Drosophila synucleinopathy model.
Yedlapudi et al.
Sci Rep., 2016;69:38510
Citation for KYP 2047
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