Catalog Number: 5085
Chemical Name: 8-Amino-5-chloro-2,3-dihydro-7-phenyl-pyrido[3,4-d]pyridazine sodium salt
Biological Activity
Luminal-based chemiluminescent probe. Detects NAPDH oxidase-derived reactive oxygen and nitrogen species (ROS and RNS). Active in vitro and in vivo.
Technical Data
  • M.Wt:
    310.67
  • Formula:
    C13H8CIN4NaO2
  • Solubility:
    Soluble to 50 mM in water and to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    143556-24-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. In vivo imaging of reactive oxygen and nitrogen species in inflammation using the luminescent probe L-012.
    Kielland et al.
    Free Radic.Biol.Med., 2009;47:760
  2. Noninvasive assessment of localized inflammatory responses.
    Zhou et al.
    Free Radic.Biol.Med., 2012;52:218
  3. Evaluation of lophine derivatives as L-012 (luminol analog)-dependent chemiluminescence enhancers for measuring horseradish peroxidase and H2 O2.
    Ichibangase et al.
    Luminescence., 2013;29:118

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