Home / PPAR delta Receptor Agonists / L-165,041

L-165,041

Catalog #: 1856
2 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
1856/10
1856/50
L-165,041 | CAS No. 79558-09-1 | PPAR delta Receptor Agonists
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Description: Potent PPARδ agonist

Chemical Name: [4-[3-(4-Acetyl-3-hydroxy-2-propylphenoxy)propoxy]phenoxy]acetic acid

Purity: ≥98%

Product Details
Citations (2)
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Biological Activity

L-165,041 is a potent PPARδ agonist (Ki = 6 nM); displays > 100-fold selectivity for both mouse and human PPARδ receptors over other subtypes. Raises plasma cholesterol levels in vivo, in insulin-resistant db/db mice. Neuroprotective in models of cerebral infarction and Parkinson's disease.

Technical Data

M.Wt:
402.44
Formula:
C22H26O7
Solubility:
Soluble to 50 mM in 1eq. NaOH and to 100 mM in DMSO
Purity:
≥98%
Storage:
Desiccate at RT
CAS No:
79558-09-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Complete Your Experiment

Human PPAR delta/NR1C2 (NP_006229) VersaClone cDNA
Cat # RDC2078

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Citations for L-165,041

The citations listed below are publications that use Tocris products. Selected citations for L-165,041 include:

2 Citations: Showing 1 - 2

  1. PPARδ Elicits Ligand-Independent Repression of Trefoil Factor Family to Limit Prostate Cancer Growth.
    Authors: Martín-Martín Et al.
    Cancer Res  2018;78:399
  2. Lipolytic products activate peroxisome proliferator-activated receptor (PPAR) α and δ in brown adipocytes to match fatty acid oxidation with supply.
    Authors: Mottillo Et al.
    J Mol Graph Model  2012;287:25038

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VersaClone cDNA Plasmids

Human PPAR delta/NR1C2 (NP_006229) VersaClone cDNA

RDC2078

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