Catalog Number: 1856
Chemical Name: [4-[3-(4-Acetyl-3-hydroxy-2-propylphenoxy)propoxy]phenoxy]acetic acid
Biological Activity
Potent PPARδ agonist (Ki = 6 nM); displays > 100-fold selectivity for both mouse and human PPARδ�receptors over other subtypes. Raises plasma cholesterol levels in vivo, in insulin-resistant db/db mice. Neuroprotective in models of cerebral infarction and Parkinson's disease.
Technical Data
  • M.Wt:
    402.44
  • Formula:
    C22H26O7
  • Solubility:
    Soluble to 100 mM in 1eq. NaOH and to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Desiccate at RT
  • CAS No:
    79558-09-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Novel peroxisome proliferator-activated receptor (PPAR)γ and PPARδ ligands produce distinct biological effects.
    Berger et al.
    J.Biol.Chem., 1999;274:6718
  2. Activation of PPARδ alters lipid metabolism in db/db mice.
    Leibowitz et al.
    FEBS Lett., 2000;473:333
  3. Neuroprotective efficacy of the peroxisome proliferator-activated receptor δ-selective agonists in vitro and in vivo.
    Iwashita et al.
    J.Pharmacol.Exp.Ther., 2007;320:1087
Citations:

The citations listed below are publications that use Tocris products. Selected citations for L-165,041 include:

1 Citations: Showing 1 - 1

  1. Lipolytic products activate peroxisome proliferator-activated receptor (PPAR) α and δ in brown adipocytes to match fatty acid oxidation with supply.
    Authors: Mottillo Et al.
    J Mol Graph Model 2012;287:25038

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