Chemical Name: [4-[3-(4-Acetyl-3-hydroxy-2-propylphenoxy)propoxy]phenoxy]acetic acid
Biological ActivityL-165,041 is a potent PPARδ agonist (Ki = 6 nM); displays > 100-fold selectivity for both mouse and human PPARδ receptors over other subtypes. Raises plasma cholesterol levels in vivo, in insulin-resistant db/db mice. Neuroprotective in models of cerebral infarction and Parkinson's disease.
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Novel peroxisome proliferator-activated receptor (PPAR)γ and PPARδ ligands produce distinct biological effects.
Berger et al.
Activation of PPARδ alters lipid metabolism in db/db mice.
Leibowitz et al.
FEBS Lett., 2000;473:333
Neuroprotective efficacy of the peroxisome proliferator-activated receptor δ-selective agonists in vitro and in vivo.
Iwashita et al.
Citations for L-165,041
The citations listed below are publications that use Tocris products. Selected citations for L-165,041 include:
2 Citations: Showing 1 - 2
PPARδ Elicits Ligand-Independent Repression of Trefoil Factor Family to Limit Prostate Cancer Growth.
Authors: Martín-Martín Et al.
Cancer Res 2018;78:399
Lipolytic products activate peroxisome proliferator-activated receptor (PPAR) α and δ in brown adipocytes to match fatty acid oxidation with supply.
Authors: Mottillo Et al.
J Mol Graph Model 2012;287:25038
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