= 6 nM); displays > 100-fold selectivity for both mouse and human PPARδ
�receptors over other subtypes. Raises plasma cholesterol levels in vivo
, in insulin-resistant db/db mice. Neuroprotective in models of cerebral infarction and Parkinson's disease.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Novel peroxisome proliferator-activated receptor (PPAR)γ and PPARδ ligands produce distinct biological effects.
Berger et al.
Activation of PPARδ alters lipid metabolism in db/db mice.
Leibowitz et al.
FEBS Lett., 2000;473:333
Neuroprotective efficacy of the peroxisome proliferator-activated receptor δ-selective agonists in vitro and in vivo.
Iwashita et al.
The citations listed below are publications that use Tocris products. Selected citations for L-165,041 include:
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