L-365,260

Key Product Details

Product Description

L-365,260 is a selective cholecystokinin receptor 2 (CCK₂) antagonist (IC₅₀ values are 2 and 280 nM at CCK₂ and CCK₁ receptors respectively) that is inactive at a range of other receptors including opiate, muscarinic acetylcholine, α- and β adrenergic, histamine, angiotensin and bradykinin receptors.

Product Specifications for L-365,260

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for L-365,260

The following data is based on the product molecular weight 398.46.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.51 mL	12.55 mL	25.10 mL
5 mM	0.50 mL	2.51 mL	5.02 mL
10 mM	0.25 mL	1.25 mL	2.51 mL
50 mM	0.05 mL	0.25 mL	0.50 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 12 publications citing the usage of this product.

• Lotti and Chang A new potent and selective non-peptide gastrin antagonist and brain cholecystokinin receptor (CCK-B) ligand: L-365,260. Eur.J.Pharmacol. 1989 PMID: 2721567
• Chung Cholecystokinin action on layer 6b neurons in somatosensory cortex. Brain Res. 2009 PMID: 19497313
• Kees Benzodiazepine gastrin and brain cholecystokinin receptor ligands: L-365,260. J.Med.Chem. 1989 PMID: 2909725

Product Documents for L-365,260