L-685,458

Catalog # Availability Size / Price Qty
2627/1
Secretase Inhibitors Small Molecule
1 Image
Description: Potent and selective γ-secretase inhibitor

Chemical Name: (5S)-(tert-Butoxycarbonylamino)-6-phenyl-(4R)-hydroxy-(2R)-benzylhexanoyl)-L-leucy-L-phenylalaninamide

Purity: ≥97%

Product Details
Citations (7)
Reviews

Biological Activity

Potent and selective γ-secretase inhibitor (IC50 = 17 nM) that displays > 50-fold selectivity over a range of aspartyl, serine and cysteine proteases. Exhibits equal potency for inhibition of Aβ40 and Aβ42 peptides (IC50 values are 48 and 67 nM respectively in human neuroblastoma cells). Also regulates CXCR4 and VEGFR2 expression through inhibition of Notch signaling in vitro.

Technical Data

M.Wt:
672.85
Formula:
C39H52N4O6
Solubility:
Soluble to 15 mM in DMSO
Purity:
≥97%
Storage:
Store at -20°C
CAS No:
292632-98-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for L-685,458

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