Potent and selective γ
-secretase inhibitor (IC50
= 17 nM) that displays > 50-fold selectivity over a range of aspartyl, serine and cysteine proteases. Exhibits equal potency for inhibition of Aβ
40 and Aβ
42 peptides (IC50
values are 48 and 67 nM respectively in human neuroblastoma cells). Also regulates CXCR4 and VEGFR2 expression through inhibition of Notch signaling in vitro
Soluble to 15 mM in DMSO
Store at -20°C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Regulation of CXCR4 by the Notch ligand delta-like 4 in endothelial cells.
Williams CK, Segarra M, Sierra Mde L et al.
L-685,458, an aspartyl protease transition state mimic, is a potent inhibitor of amyloid-β-protein precursor γ-secretase activity.
Shearman et al.
Up-regulation of the Notch ligand delta-like 4 inhibits VEGF-induced endothelial cell function.
Williams et al.
The citations listed below are publications that use Tocris products. Selected citations for L-685,458 include:
Showing Results 1 - 1 of 1