L-685,458

  ( 3 citations )    
Product Datasheet
Catalog Number:2627
Chemical Name:(5S)-(tert-Butoxycarbonylamino)-6-phenyl-(4R)-hydroxy-(2R)-benzylhexanoyl)-L-leucy-L-phenylalaninamide
Product Details
Citations (3)
Reviews
Biological Activity
Potent and selective γ-secretase inhibitor (IC50 = 17 nM) that displays > 50-fold selectivity over a range of aspartyl, serine and cysteine proteases. Exhibits equal potency for inhibition of Aβ40 and Aβ42 peptides (IC50 values are 48 and 67 nM respectively in human neuroblastoma cells). Also regulates CXCR4 and VEGFR2 expression through inhibition of Notch signaling in vitro.
Technical Data
  • M.Wt:
    672.85
  • Formula:
    C39H52N4O6
  • Solubility:
    Soluble to 15 mM in DMSO
  • Purity:
    >97
  • Storage:
    Store at -20°C
  • CAS No:
    292632-98-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for L-685,458 include:

3 Citations: Showing 1 - 3
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  1. RAGE inhibition in microglia prevents ischemia-dependent synaptic dysfunction in an amyloid-enriched environment.
    Authors: Origlia Et al.
    J Neurosci  2014;34:8749
  2. γ-Secretase processing and effects of γ-secretase inhibitors and modulators on long Aβ peptides in cells.
    Authors: Ran Et al.
    J Biol Chem  2014;289:3276
  3. Canonical Notch signalling is inactive in urothelial carcinoma.
    Authors: Greife Et al.
    BMC Cancer  2014;14:628

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