L-690,330

Key Product Details

Product Description

L-690,330 is a potent inhibitor of inositol monophophatase; stable to hydrolysis. Induces autophagy in COS-7 cells independently of mTOR inhibition.

Licensing Information

Sold with the permission of Merck Sharp and Dohme Ltd.

Product Specifications for L-690,330

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for L-690,330

The following data is based on the product molecular weight 298.13.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

3 2 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	16.77 mL	83.86 mL	167.71 mL
1 mM	3.35 mL	16.77 mL	33.54 mL
2 mM	1.68 mL	8.39 mL	16.77 mL
10 mM	0.34 mL	1.68 mL	3.35 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 19 publications citing the usage of this product.

• Sarkar Li induces autophagy by inhibiting inositol monophosphatase. J.Cell.Biol. 2005 PMID: 16186256
• Atack Effects of L-690,488, a pro-drug of the bisphosphonate inisotol monophosphatase inhibitor L-690,330, on phosphatidylinisotol cycle markers. J.Pharmacol.Exp.Ther. 1994 PMID: 8035344
• Fleming Chemical modulators of autophagy as biological probes and potential therapeutics. Nat.Chem.Biol. 2011 PMID: 21164513
• Atack In vitro and in vivo inhibition of inositol monophosphatase by the bisphosphonate L-690,330. J.Neurochem. 1993 PMID: 8380439

Product Documents for L-690,330