Highly potent, non-peptide ghrelin receptor (GHS-R1a) agonist (Ki
= 0.8 nM). Increases plasma GH levels in vivo
and is 2- to 2.5-fold more potent than GHRP-6.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Effects of acute and repeated intravenous administration of L-692,585, a novel non-peptidyl growth hormone secretagogue, on plasma growth hormone, IGF-1, ACTH, cortisol, prolactin, insulin, and thyroxine levels in beagles.
Jacks et al.
Mechanism of action of the growth hormone secretagogue, L-692,585, on isolated porcine somatotropes.
Glavaski-Joksimovic et al.
Peptidomimetic regulation of growth hormone secretion.
Smith et al.
Endocrine Rev., 1999;18:621