L-692,585

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L-692,585 | CAS No. 145455-35-2 | Ghrelin Receptor Agonists
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Description: Potent, non-peptide ghrelin receptor agonist

Chemical Name: 3-[[(2R)-2-Hydroxypropyl]amino]-3-methyl-N-[(3R)-2,3,4,5-tetrahydro-2-oxo-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-1-benzazepin-3-yl]-butanamide

Purity: ≥98%

Product Details
Citations (1)
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Reviews

Biological Activity

Highly potent, non-peptide ghrelin receptor (GHS-R1a) agonist (Ki = 0.8 nM). Increases plasma GH levels in vivo and is 2- to 2.5-fold more potent than GHRP-6.

Technical Data

M.Wt:
567.69
Formula:
C32H37N7O3
Solubility:
Soluble to 100 mM in DMSO and to 25 mM in ethanol
Purity:
≥98%
Storage:
Desiccate at -20°C
CAS No:
145455-35-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Effects of acute and repeated intravenous administration of L-692,585, a novel non-peptidyl GH secretagogue, on plasma GH, IGF-1, ACTH, cortisol, prolactin, Ins, and thyroxine levels in beagles.
    Jacks et al.
    J.Endocrinol., 1994;143:399
  2. Mechanism of action of the GH secretagogue, L-692,585, on isolated porcine somatotropes.
    Glavaski-Joksimovic et al.
    J.Endocrinol., 2002;175:625
  3. Peptidomimetic regulation of GH secretion.
    Smith et al.
    Endocrine Rev., 1999;18:621

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Citation for L-692,585

The citations listed below are publications that use Tocris products. Selected citations for L-692,585 include:

1 Citation: Showing 1 - 1

  1. G Protein and β-arrestin signaling bias at the ghrelin receptor.
    Authors: Evron Et al.
    J Biol Chem  2014;289:33442

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