Catalog Number: 2261
Chemical Name: 3-[[(2R)-2-Hydroxypropyl]amino]-3-methyl-N-[(3R)-2,3,4,5-tetrahydro-2-oxo-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-1-benzazepin-3-yl]-butanamide
Biological Activity
Highly potent, non-peptide ghrelin receptor (GHS-R1a) agonist (Ki = 0.8 nM). Increases plasma GH levels in vivo and is 2- to 2.5-fold more potent than GHRP-6.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO and to 25 mM in ethanol
  • Purity:
  • Storage:
    Desiccate at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Effects of acute and repeated intravenous administration of L-692,585, a novel non-peptidyl growth hormone secretagogue, on plasma growth hormone, IGF-1, ACTH, cortisol, prolactin, insulin, and thyroxine levels in beagles.
    Jacks et al.
    J.Endocrinol., 1994;143:399
  2. Mechanism of action of the growth hormone secretagogue, L-692,585, on isolated porcine somatotropes.
    Glavaski-Joksimovic et al.
    J.Endocrinol., 2002;175:625
  3. Peptidomimetic regulation of growth hormone secretion.
    Smith et al.
    Endocrine Rev., 1999;18:621
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