L-732,138
Chemical Name: N-Acetyl-L-tryptophan 3,5-bis(trifluoromethyl)benzyl ester
Purity: ≥98%
Biological Activity
L-732,138 is a potent and highly selective competitive tachykinin NK1 receptor antagonist (IC50 = 2.3 nM).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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Characterization of the interaction of N-acyl-L-tryptophan benzyl ester neurokinin antagonists with the human neurokinin-1 receptor.
Cascieri et al.
J.Biol.Chem., 1994;269:6587 -
Lipopolysaccharide enhances neurogenic plasma exudation in guinea-pig airways.
Kuo et al.
Br.J.Pharmacol., 1998;125:711 -
N-Acyl-L-tryptophan benzyl esters: potent substance P receptor antagonists.
MacLeod et al.
J.Med.Chem., 1993;36:2044 -
Identification of L-tryptophan derivatives with potent and selective antagonist activity at the NK1 receptor.
MacLeod et al.
J.Med.Chem., 1994;37:1269
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Citations for L-732,138
The citations listed below are publications that use Tocris products. Selected citations for L-732,138 include:
2 Citations: Showing 1 - 2
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Endomorphin-2 Inhibition of Substance P Signaling within Lamina I of the Spinal Cord Is Impaired in Diabetic Neuropathic Pain Rats.
Authors: Wan Et al.
Front Mol Neurosci 2017;9:167
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Neurotransmitter substance P mediates pancreatic cancer perineural invasion via NK-1R in cancer cells.
Authors: Li Et al.
J Neurosci 2013;11:294
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