Chemical Name: N-Acetyl-L-tryptophan 3,5-bis(trifluoromethyl)benzyl ester
Biological ActivityL-732,138 is a potent and highly selective competitive tachykinin NK1 receptor antagonist (IC50 = 2.3 nM).
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Characterization of the interaction of N-acyl-L-tryptophan benzyl ester neurokinin antagonists with the human neurokinin-1 receptor.
Cascieri et al.
Lipopolysaccharide enhances neurogenic plasma exudation in guinea-pig airways.
Kuo et al.
N-Acyl-L-tryptophan benzyl esters: potent substance P receptor antagonists.
MacLeod et al.
Identification of L-tryptophan derivatives with potent and selective antagonist activity at the NK1 receptor.
MacLeod et al.
Citations for L-732,138
The citations listed below are publications that use Tocris products. Selected citations for L-732,138 include:
2 Citations: Showing 1 - 2
Endomorphin-2 Inhibition of Substance P Signaling within Lamina I of the Spinal Cord Is Impaired in Diabetic Neuropathic Pain Rats.
Authors: Wan Et al.
Front Mol Neurosci 2017;9:167
Neurotransmitter substance P mediates pancreatic cancer perineural invasion via NK-1R in cancer cells.
Authors: Li Et al.
J Neurosci 2013;11:294
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