Catalog Number: 0868
Chemical Name: N-Acetyl-L-tryptophan 3,5-bis(trifluoromethyl)benzyl ester
Biological Activity
Potent and highly selective competitive tachykinin NK1 receptor antagonist (IC50 = 2.3 nM).
Technical Data
  • M.Wt:
    472.39
  • Formula:
    C22H18F6N2O3
  • Solubility:
    Soluble to 100 mM in ethanol and to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at RT
  • CAS No:
    148451-96-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of Merck Sharp and Dohme Ltd.
Background References
  1. Characterization of the interaction of N-acyl-L-tryptophan benzyl ester neurokinin antagonists with the human neurokinin-1 receptor.
    Cascieri et al.
    J.Biol.Chem., 1994;269:6587
  2. Lipopolysaccharide enhances neurogenic plasma exudation in guinea-pig airways.
    Kuo et al.
    Br.J.Pharmacol., 1998;125:711
  3. N-Acyl-L-tryptophan benzyl esters: potent substance P receptor antagonists.
    MacLeod et al.
    J.Med.Chem., 1993;36:2044
  4. Identification of L-tryptophan derivatives with potent and selective antagonist activity at the NK1 receptor.
    MacLeod et al.
    J.Med.Chem., 1994;37:1269
Citations:

The citations listed below are publications that use Tocris products. Selected citations for L-732,138 include:

1 Citations: Showing 1 - 1

  1. Neurotransmitter substance P mediates pancreatic cancer perineural invasion via NK-1R in cancer cells.
    Authors: Li Et al.
    J Neurosci 2013;11:294

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