L-741,626

Key Product Details

Product Description

L-741,626 is a potent D₂ dopamine receptor selective antagonist, with affinities of 2.4, 100 and 220 nM for D₂, D₃ and D₄ receptors respectively. Centrally active following systemic administration in vivo.

Licensing Information

Sold with the permission of Merck Sharp and Dohme Ltd.

Product Specifications for L-741,626

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for L-741,626

The following data is based on the product molecular weight 340.85.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.93 mL	14.67 mL	29.34 mL
5 mM	0.59 mL	2.93 mL	5.87 mL
10 mM	0.29 mL	1.47 mL	2.93 mL
50 mM	0.06 mL	0.29 mL	0.59 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 86 publications citing the usage of this product.

• Pillai Human D2 and D4 DA receptors couple through βγ G-protein subunits to inwardly rectifying K+ channels (GIRK1) in a Xenopus oocyte expression system: selective antagonism by L-741,626 and L-745,870 respect Neuropharmacology 1998 PMID: 9833627
• Kulagowski 3-[[4-(4-Chlorophenyl)piperazin-1-yl]methyl]-1H-pyrrolo[2,3-b]pyridine: an antagonist with high affinity and selectivity for the human DA D₄ receptor. J.Med.Chem. 1996 PMID: 8642550
• Millan S33084, a novel, potent, selective, and competitive antagonist at DA D₃-receptors: II. Functional and behavioral profile compared with GR218,231 and L741,626. J.Pharmacol.Exp.Ther. 2000 PMID: 10869411
• Bowery Antagonism of the effects of (+)-PD 128907 on midbrain DA neurones in rat brain slices by a selective D₂ receptor antagonist L-741,626. Br.J.Pharmacol. 1996 PMID: 8968560

Product Documents for L-741,626