Compounds for Induced Pluripotent Stem Cells: Products


Induced pluripotent stem (iPS) cells were first generated from fibroblasts by exogenously expressing four transcription factors: KLF4, c-Myc, Oct-4, and SOX2. However, somatic cell reprogramming can be inefficient, and the use of viral vectors can complicate their therapeutic potential. Thus, bioactive small molecules are important tools for optimizing iPS cell generation and research. Compounds such as Thiazovivin can be added to culture media to enhance the efficiency of iPS cell generation. Chromatin modifying small molecules, such as those that target histone deacetylases (HDACs) or methyltransferases, can also aid in somatic cell reprogramming by opening chromatin and promoting the transcription of pluripotency genes. In fact, following epigenetic changes induced by Valproic Acid, a HDAC inhibitor, iPS cells can be generated from somatic cells with the introduction of only Oct-4 and SOX2. Recent reports indicate that small molecules can also replace the function of particular transcription factors. For example, Kenpaullone, a Cyclin Dependent Kinase and GSK-3 beta inhibitor, can replace KLF4. Tocris provides a complete range of small molecules to optimize somatic cell reprogramming and reduce the need for viral-mediated transduction of transcription factors.

"Compounds for Induced Pluripotent Stem Cells" has 42 results in Products.
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SB 431542 

Potent, selective inhibitor of TGF-βRI, ALK4 and ALK7

SB 431542 

SB 431542 synthesized to cGMP guidelines

CHIR 99021 

Highly selective GSK-3 inhibitor; acts as Wnt activator

3-Deazaneplanocin A hydrochloride 

EZH2 histone methyltransferase inhibitor

CHIR 99021 

CHIR 99021 synthesized to cGMP guidelines

A 83-01 

Selective inhibitor of TGF-βRI, ALK4 and ALK7

XAV 939 

Potent tankyrase inhibitor

IWP 2 

PORCN inhibitor; inhibits Wnt processing and secretion

L-Ascorbic acid 

Enhances the generation of iPSCs; increases reprogramming efficiency


Potent and selective inhibitor of TGF-βRI

PD 0325901 

Potent inhibitor of MEK1/2

endo-IWR 1 

Wnt/β-catenin signaling inhibitor; axin stabilizer


ROCK inhibitor; improves the efficiency of fibroblast reprogramming and induction of iPSCs

CKI 7 dihydrochloride 

CK1 inhibitor

XAV 939 

XAV 939 synthesized to cGMP guidelines

LY 294002 hydrochloride 

Prototypical PI 3-kinase inhibitor; also inhibits other kinases

Valproic acid, sodium salt 

Histone deacetylase inhibitor


Inhibitor of Hedgehog (Hh) signaling

IWP 4 

Potent inhibitor of Wnt/β-catenin signaling


Retinoic acid analog; RAR agonist

Trichostatin A 

Potent histone deacetylase inhibitor

Sodium butyrate 

Histone deacetylase inhibitor

Pifithrin-α hydrobromide 

p53 inhibitor. Also aryl hydrocarbon receptor agonist

(±)-Bay K 8644 

CaV1.x activator

Tranylcypromine hydrochloride 

Irreversible inhibitor of LSD1; also inhibits MAO

IDE 1 

Induces definitive endoderm formation in mouse and human ESCs

Polyamine Supplement x1000 (lyophilized) 

Media supplement to boost cell growth; used as component of CEPT cocktail to enhance stem cell viability


RepSox synthesized to Ancillary Material Grade


DNA methyltransferase inhibitor

KY 02111 

Inhibits canonical Wnt signaling. Promotes differentiation of human ESCs and iPSCs into cardiomyocytes

A 83-01 

A 83-01 synthesized to Ancillary Material Grade


GSK-3β inhibitor; also inhibits cdks


Inhibitor of p53-mitochondrial binding

RG 108 

Non-nucleoside DNA methyltransferase inhibitor

QS 11 

ARFGAP1 inhibitor; modulates Wnt/β-catenin signaling

BIX 01294 

GLP and G9a inhibitor

SR 3677 dihydrochloride 

Potent, selective Rho-kinase (ROCK) inhibitor

PluriSln 1 

SCD-1 inhibitor


Oct3/4 inducer; induces expression of pluripotent-associated genes


T3 synthesized to Ancillary Material Grade

endo-IWR 1 

endo-IWR 1 synthesized to Ancillary Material Grade

L-Ascorbic acid 

L-Ascorbic acid synthesized to Ancillary Material Grade
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