Compounds for Induced Pluripotent Stem Cells: Products

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Induced pluripotent stem (iPS) cells were first generated from fibroblasts by exogenously expressing four transcription factors: KLF4, c-Myc, Oct-4, and SOX2. However, somatic cell reprogramming can be inefficient, and the use of viral vectors can complicate their therapeutic potential. Thus, bioactive small molecules are important tools for optimizing iPS cell generation and research. Compounds such as Thiazovivin can be added to culture media to enhance the efficiency of iPS cell generation. Chromatin modifying small molecules, such as those that target histone deacetylases (HDACs) or methyltransferases, can also aid in somatic cell reprogramming by opening chromatin and promoting the transcription of pluripotency genes. In fact, following epigenetic changes induced by Valproic Acid, a HDAC inhibitor, iPS cells can be generated from somatic cells with the introduction of only Oct-4 and SOX2. Recent reports indicate that small molecules can also replace the function of particular transcription factors. For example, Kenpaullone, a Cyclin Dependent Kinase and GSK-3 beta inhibitor, can replace KLF4. Tocris provides a complete range of small molecules to optimize somatic cell reprogramming and reduce the need for viral-mediated transduction of transcription factors.

"Compounds for Induced Pluripotent Stem Cells" has 43 results in Products.
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SB 431542 

Potent, selective inhibitor of TGF-βRI, ALK4 and ALK7

SB 431542 

SB 431542 synthesized to cGMP guidelines

CHIR 99021 

Highly selective GSK-3 inhibitor; acts as Wnt activator

CHIR 99021 

CHIR 99021 synthesized to cGMP guidelines

A 83-01 

Selective inhibitor of TGF-βRI, ALK4 and ALK7

3-Deazaneplanocin A hydrochloride 

EZH2 histone methyltransferase inhibitor

IWP 2 

PORCN inhibitor; inhibits Wnt processing and secretion

XAV 939 

Potent tankyrase inhibitor

PD 0325901 

Potent inhibitor of MEK1/2

endo-IWR 1 

Wnt/β-catenin signaling inhibitor; axin stabilizer

L-Ascorbic acid 

Enhances the generation of iPSCs; increases reprogramming efficiency

Thiazovivin 

ROCK inhibitor ; improves the efficiency of fibroblast reprogramming and induction of iPSCs

Valproic acid, sodium salt 

Histone deacetylase inhibitor

RepSox 

Potent and selective inhibitor of TGF-βRI

LY 294002 hydrochloride 

Prototypical PI 3-kinase inhibitor; also inhibits other kinases

Cyclopamine 

Inhibitor of Hedgehog (Hh) signaling

Trichostatin A 

Potent histone deacetylase inhibitor

5-Azacytidine 

DNA methyltransferase inhibitor

XAV 939 

XAV 939 synthesized to cGMP guidelines

IWP 4 

Potent inhibitor of Wnt/β-catenin signaling

TTNPB 

Retinoic acid analog; RAR agonist

Pifithrin-α hydrobromide 

p53 inhibitor. Also aryl hydrocarbon receptor agonist

(±)-Bay K 8644 

CaV1.x activator

BIX 01294 

GLP and G9a inhibitor

Kenpaullone 

GSK-3β inhibitor; also inhibits cdks

Pifithrin-μ 

Inhibitor of p53-mitochondrial binding

RG 108 

Non-nucleoside DNA methyltransferase inhibitor

Sodium butyrate 

Histone deacetylase inhibitor

Tranylcypromine hydrochloride 

Irreversible inhibitor of LSD1; also inhibits MAO

IDE 1 

Induces definitive endoderm formation in mouse and human ESCs

IDE 2 

Induces definitive endoderm formation in mouse and human ESCs

IQ 1 

Enables Wnt/β-catenin-driven expansion of ESCs; prevents spontaneous differentiation

PluriSln 1 

SCD-1 inhibitor

CKI 7 dihydrochloride 

CK1 inhibitor

QS 11 

ARFGAP1 inhibitor; modulates Wnt/β-catenin signaling

SR 3677 dihydrochloride 

Potent, selective Rho-kinase (ROCK) inhibitor

Cardiogenol C hydrochloride 

Induces cardiomyocyte differentiation in ESCs

Cardionogen 1 

Inhibitor of Wnt/β-catenin signaling

O4I2 

Oct3/4 inducer; induces expression of pluripotent-associated genes

ID 8 

Sustains self-renewal and pluripotency of ESCs

KY 02111 

Inhibits canonical Wnt signaling. Promotes differentiation of human ESCs and iPSCs into cardiomyocytes

OAC-1 

Oct4 activator; enhances iPSC reprogramming efficiency

RepSox 

RepSox synthesized to Ancillary Material Grade
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