Chemical Name: 6-Diazo-5-oxo-L-norleucine
Biological ActivityGlutaminase inhibitor (Ki = 6 μM). Also inhibits other glutamine-using enzymes, amino acid transporters and transglutaminases. Displays antitumor effects and reduces tumor weight in a range of mouse xenograft models.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Efficacy of 6-diazo-5-oxo-L-norleucine and N-[N-γ-glutamyl-6-diazo-5-oxo-norleucinyl]-6-diazo-5-oxo-norleucine against experimental tumors in conventional and nude mice.
Ovejera et al.
Cancer Res., 1979;39:3220
We're not "DON" yet: optimal dosing and prodrug delivery of 6-diazo-5-oxo-L-norleucine.
Lemberg et al.
Mol.Cancer Ther., 2018;17:1824
Kinetic characterization of ebselen, chelerythrine and apomor. as glutaminase inhibitors.
Thomas et al.
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