Latrunculin A

Catalog # Availability Size / Price Qty
3973/100U
Latrunculin A | CAS No. 76343-93-6 | Actin-related Products
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Description: Inhibitor of actin assembly and polymerization

Chemical Name: 4-[(1R,4Z,8E,10Z,12S,15R, 17R)-17-Hydroxy-5,12-dimethyl-3-oxo-2,16-dioxabicyclo[13.3.1]nonadeca-4,8,10-trien-17-yl)-2-thiazolidinone

Product Details
Citations (19)
Reviews

Biological Activity

Reversible inhibitor of actin assembly; blocks actin adenine nucleotide exchange. Complexes with actin in vitro and interacts with actin monomers only, unlike cytochalasins. Prevents actin repolymerization into filaments and disrupts the actin cytoskeleton.

Technical Data

M.Wt:
421.55
Formula:
C22H31NO5S
Solubility:
Soluble to 10 mM in DMSO
Storage:
Store at -20°C
CAS No:
76343-93-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Actin-latrunculin A structure and function.
    Yarmola et al.
    J.Biol.Chem., 2000;275:28120
  2. Latrunculin alters the actin-monomer subunit interface to prevent polymerization.
    Morton et al.
    Nat.Cell Biol., 2000;2:376
  3. On the chemistry of latrunculins A and B.
    Blasberger et al.
    Liebigs.Ann.Chem., 1989;1989:1171

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Citations for Latrunculin A

The citations listed below are publications that use Tocris products. Selected citations for Latrunculin A include:

19 Citations: Showing 1 - 10

  1. RAC1P29S Induces a Mesenchymal Phenotypic Switch via Serum Response Factor to Promote Melanoma Development and Therapy Resistance.
    Authors: Lionarons Et al.
    Cancer Cell  2019;36:68
  2. Identification of the kinase STK25 as an upstream activator of LATS signaling.
    Authors: Lim Et al.
    Nat Commun  2019;10:1547
  3. Spike-timing-dependent plasticity rule for single, clustered and distributed dendritic spines
    Authors: Tazerart Et al.
    BioRXiv  2019;
  4. Matrix mechanical plasticity regulates cancer cell migration through confining microenvironments.
    Authors: Wisdom Et al.
    Nat Commun  2018;9:4144
  5. Cell-intrinsic and -extrinsic mechanisms promote cell-type-specific cytokinetic diversity.
    Authors: Davies Et al.
    Elife  2018;7
  6. Coordination of Receptor Tyrosine Kinase Signaling and Interfacial Tension Dynamics Drives Radial Intercalation and Tube Elongation.
    Authors: Neumann Et al.
    Dev Cell  2018;45:67
  7. Mechanistic peculiarities of activation-induced mobilization of cytotoxic effector proteins in human T cells.
    Authors: Lettau Et al.
    Int Immunol  2018;30:215
  8. The Actin Nucleator Cobl Is Critical for Centriolar Positioning, Postnatal Planar Cell Polarity Refinement, and Function of the Cochlea.
    Authors: Haag Et al.
    Cell Rep  2018;24:2418
  9. Excitable Dynamics and Yap-Dependent Mechanical Cues Drive the Segmentation Clock.
    Authors: Hubaud Et al.
    Cell  2017;171:668
  10. Bronchoconstriction Induces TGF-β Release and Airway Remodelling in Guinea Pig Lung Slices.
    Authors: Oenema Et al.
    Oncotarget  2016;8:e65580

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