Chemical Name: 4-[(1R,4Z,8E,10Z,12S,15R, 17R)-17-Hydroxy-5,12-dimethyl-3-oxo-2,16-dioxabicyclo[13.3.1]nonadeca-4,8,10-trien-17-yl)-2-thiazolidinone
Biological ActivityLatrunculin A is a reversible inhibitor of actin assembly; blocks actin adenine nucleotide exchange. Complexes with actin in vitro and interacts with actin monomers only, unlike cytochalasins. Prevents actin repolymerization into filaments and disrupts the actin cytoskeleton.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Actin-latrunculin A structure and function.
Yarmola et al.
Latrunculin alters the actin-monomer subunit interface to prevent polymerization.
Morton et al.
Nat.Cell Biol., 2000;2:376
On the chemistry of latrunculins A and B.
Blasberger et al.
Citations for Latrunculin A
The citations listed below are publications that use Tocris products. Selected citations for Latrunculin A include:
19 Citations: Showing 1 - 10
A spike-timing-dependent plasticity rule for dendritic spines.
Authors: Tazerart Et al.
Nat Commun 2020;11:4276
RAC1P29S Induces a Mesenchymal Phenotypic Switch via Serum Response Factor to Promote Melanoma Development and Therapy Resistance.
Authors: Lionarons Et al.
Cancer Cell 2019;36:68
Identification of the kinase STK25 as an upstream activator of LATS signaling.
Authors: Lim Et al.
Nat Commun 2019;10:1547
Matrix mechanical plasticity regulates cancer cell migration through confining microenvironments.
Authors: Wisdom Et al.
Nat Commun 2018;9:4144
Cell-intrinsic and -extrinsic mechanisms promote cell-type-specific cytokinetic diversity.
Authors: Davies Et al.
Coordination of Receptor Tyrosine Kinase Signaling and Interfacial Tension Dynamics Drives Radial Intercalation and Tube Elongation.
Authors: Neumann Et al.
Dev Cell 2018;45:67
Mechanistic peculiarities of activation-induced mobilization of cytotoxic effector proteins in human T cells.
Authors: Lettau Et al.
Int Immunol 2018;30:215
The Actin Nucleator Cobl Is Critical for Centriolar Positioning, Postnatal Planar Cell Polarity Refinement, and Function of the Cochlea.
Authors: Haag Et al.
Cell Rep 2018;24:2418
Excitable Dynamics and Yap-Dependent Mechanical Cues Drive the Segmentation Clock.
Authors: Hubaud Et al.
Bronchoconstriction Induces TGF-β Release and Airway Remodelling in Guinea Pig Lung Slices.
Authors: Oenema Et al.
The role of Rab6a and phosphorylation of non-muscle myosin IIA tailpiece in alcohol-induced Golgi disorganization.
Authors: Petrosyan Et al.
Sci Rep 2016;6:31962
Regulation of actin dynamics by WNT-5A: implications for human airway smooth muscle contraction.
Authors: Koopmans Et al.
Sci Rep 2016;6:30676
Macrophages redirect phagocytosis by non-professional phagocytes and influence inflammation
Authors: Han Et al.
Rapid dispersion of SynGAP from synaptic spines triggers AMPA receptor insertion and spine enlargement during LTP.
Authors: Araki Et al.
PLoS One 2015;85:173
Spatiotemporal quantification of subcellular ATP levels in a single HeLa cell during changes in morphology.
Authors: Suzuki Et al.
Rhinovirus-induced macrophage cytokine expression does not require endocytosis or replication.
Authors: Saba Et al.
Am J Respir Cell Mol Biol 2014;50:974
Arhgef7 promotes activation of the Hippo pathway core kinase Lats.
Authors: Arash Et al.
EMBO J 2014;33:2997
Biased inheritance of mitochondria during asymmetric cell division in the mouse oocyte.
Authors: Dalton and Carroll
J Cell Sci 2013;126:2955
Analyzing fission yeast multidrug resistance mechanisms to develop a genetically tractable model system for chemical biology.
Authors: Kawashima Et al.
Chem Biol 2012;19:893
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