Chemical Name: 4-[(1R,4Z,8E,10Z,12S,15R, 17R)-17-Hydroxy-5,12-dimethyl-3-oxo-2,16-dioxabicyclo[13.3.1]nonadeca-4,8,10-trien-17-yl)-2-thiazolidinone
Biological ActivityReversible inhibitor of actin assembly; blocks actin adenine nucleotide exchange. Complexes with actin in vitro and interacts with actin monomers only, unlike cytochalasins. Prevents actin repolymerization into filaments and disrupts the actin cytoskeleton.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Actin-latrunculin A structure and function.
Yarmola et al.
Latrunculin alters the actin-monomer subunit interface to prevent polymerization.
Morton et al.
Nat.Cell Biol., 2000;2:376
On the chemistry of latrunculins A and B.
Blasberger et al.
Citations for Latrunculin A
The citations listed below are publications that use Tocris products. Selected citations for Latrunculin A include:
14 Citations: Showing 1 - 10
Matrix mechanical plasticity regulates cancer cell migration through confining microenvironments.
Authors: Wisdom Et al.
Nat Commun 2018;9:4144
Cell-intrinsic and -extrinsic mechanisms promote cell-type-specific cytokinetic diversity.
Authors: Davies Et al.
Coordination of Receptor Tyrosine Kinase Signaling and Interfacial Tension Dynamics Drives Radial Intercalation and Tube Elongation.
Authors: Neumann Et al.
Dev Cell 2018;45:67
Excitable Dynamics and Yap-Dependent Mechanical Cues Drive the Segmentation Clock.
Authors: Hubaud Et al.
Bronchoconstriction Induces TGF-β Release and Airway Remodelling in Guinea Pig Lung Slices.
Authors: Oenema Et al.
The role of Rab6a and phosphorylation of non-muscle myosin IIA tailpiece in alcohol-induced Golgi disorganization.
Authors: Petrosyan Et al.
Sci Rep 2016;6:31962
Regulation of actin dynamics by WNT-5A: implications for human airway smooth muscle contraction.
Authors: Koopmans Et al.
Sci Rep 2016;6:30676
Macrophages redirect phagocytosis by non-professional phagocytes and influence inflammation
Authors: Han Et al.
Rapid dispersion of SynGAP from synaptic spines triggers AMPA receptor insertion and spine enlargement during LTP.
Authors: Araki Et al.
PLoS One 2015;85:173
Spatiotemporal quantification of subcellular ATP levels in a single HeLa cell during changes in morphology.
Authors: Suzuki Et al.
Rhinovirus-induced macrophage cytokine expression does not require endocytosis or replication.
Authors: Saba Et al.
Am J Respir Cell Mol Biol 2014;50:974
Arhgef7 promotes activation of the Hippo pathway core kinase Lats.
Authors: Arash Et al.
EMBO J 2014;33:2997
Biased inheritance of mitochondria during asymmetric cell division in the mouse oocyte.
Authors: Dalton and Carroll
J Cell Sci 2013;126:2955
Analyzing fission yeast multidrug resistance mechanisms to develop a genetically tractable model system for chemical biology.
Authors: Kawashima Et al.
Chem Biol 2012;19:893
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