Catalog Number: 3973
Chemical Name: 4-[(1R,4Z,8E,10Z,12S,15R, 17R)-17-Hydroxy-5,12-dimethyl-3-oxo-2,16-dioxabicyclo[13.3.1]nonadeca-4,8,10-trien-17-yl)-2-thiazolidinone
Biological Activity
Reversible inhibitor of actin assembly; blocks actin adenine nucleotide exchange. Complexes with actin in vitro and interacts with actin monomers only, unlike cytochalasins. Prevents actin repolymerization into filaments and disrupts the actin cytoskeleton.
Technical Data
  • M.Wt:
    421.55
  • Formula:
    C22H31NO5S
  • Solubility:
    Soluble to 10 mM in DMSO
  • Storage:
    Store at -20°C
  • CAS No:
    76343-93-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Actin-latrunculin A structure and function.
    Yarmola et al.
    J.Biol.Chem., 2000;275:28120
  2. Latrunculin alters the actin-monomer subunit interface to prevent polymerization.
    Morton et al.
    Nat.Cell Biol., 2000;2:376
  3. On the chemistry of latrunculins A and B.
    Blasberger et al.
    Liebigs.Ann.Chem., 1989;1989:1171
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Latrunculin A include:

6 Citations: Showing 1 - 6
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  1. Bronchoconstriction Induces TGF-β Release and Airway Remodelling in Guinea Pig Lung Slices.
    Authors: Oenema Et al.
    Oncotarget 2016;8:e65580
  2. Macrophages redirect phagocytosis by non-professional phagocytes and influence inflammation
    Authors: Han Et al.
    Nature 2016;539:570
  3. Rapid dispersion of SynGAP from synaptic spines triggers AMPA receptor insertion and spine enlargement during LTP.
    Authors: Araki Et al.
    PLoS One 2015;85:173
  4. Spatiotemporal quantification of subcellular ATP levels in a single HeLa cell during changes in morphology.
    Authors: Suzuki Et al.
    Neuron 2015;5:16874
  5. Arhgef7 promotes activation of the Hippo pathway core kinase Lats.
    Authors: Arash Et al.
    EMBO J 2014;33:2997
  6. Biased inheritance of mitochondria during asymmetric cell division in the mouse oocyte.
    Authors: Dalton and Carroll
    J Cell Sci 2013;126:2955

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