Latrunculin A

Catalog # Availability Size / Price Qty
Latrunculin A | CAS No. 76343-93-6 | Actin-related Products
1 Image
Description: Inhibitor of actin assembly and polymerization

Chemical Name: 4-[(1R,4Z,8E,10Z,12S,15R, 17R)-17-Hydroxy-5,12-dimethyl-3-oxo-2,16-dioxabicyclo[13.3.1]nonadeca-4,8,10-trien-17-yl)-2-thiazolidinone

Purity: ≥95%

Product Details
Citations (19)

Biological Activity

Latrunculin A is a reversible inhibitor of actin assembly; blocks actin adenine nucleotide exchange. Complexes with actin in vitro and interacts with actin monomers only, unlike cytochalasins. Prevents actin repolymerization into filaments and disrupts the actin cytoskeleton.

Technical Data

Soluble to 10 mM in DMSO
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Actin-latrunculin A structure and function.
    Yarmola et al.
    J.Biol.Chem., 2000;275:28120
  2. Latrunculin alters the actin-monomer subunit interface to prevent polymerization.
    Morton et al.
    Nat.Cell Biol., 2000;2:376
  3. On the chemistry of latrunculins A and B.
    Blasberger et al.
    Liebigs.Ann.Chem., 1989;1989:1171

Product Datasheets

Or select another batch:
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Molarity Calculator


*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Citations for Latrunculin A

The citations listed below are publications that use Tocris products. Selected citations for Latrunculin A include:

19 Citations: Showing 1 - 10

  1. A spike-timing-dependent plasticity rule for dendritic spines.
    Authors: Tazerart Et al.
    Nat Commun  2020;11:4276
  2. RAC1P29S Induces a Mesenchymal Phenotypic Switch via Serum Response Factor to Promote Melanoma Development and Therapy Resistance.
    Authors: Lionarons Et al.
    Cancer Cell  2019;36:68
  3. Identification of the kinase STK25 as an upstream activator of LATS signaling.
    Authors: Lim Et al.
    Nat Commun  2019;10:1547
  4. Matrix mechanical plasticity regulates cancer cell migration through confining microenvironments.
    Authors: Wisdom Et al.
    Nat Commun  2018;9:4144
  5. Cell-intrinsic and -extrinsic mechanisms promote cell-type-specific cytokinetic diversity.
    Authors: Davies Et al.
    Elife  2018;7
  6. Coordination of Receptor Tyrosine Kinase Signaling and Interfacial Tension Dynamics Drives Radial Intercalation and Tube Elongation.
    Authors: Neumann Et al.
    Dev Cell  2018;45:67
  7. Mechanistic peculiarities of activation-induced mobilization of cytotoxic effector proteins in human T cells.
    Authors: Lettau Et al.
    Int Immunol  2018;30:215
  8. The Actin Nucleator Cobl Is Critical for Centriolar Positioning, Postnatal Planar Cell Polarity Refinement, and Function of the Cochlea.
    Authors: Haag Et al.
    Cell Rep  2018;24:2418
  9. Excitable Dynamics and Yap-Dependent Mechanical Cues Drive the Segmentation Clock.
    Authors: Hubaud Et al.
    Cell  2017;171:668
  10. Bronchoconstriction Induces TGF-β Release and Airway Remodelling in Guinea Pig Lung Slices.
    Authors: Oenema Et al.
    Oncotarget  2016;8:e65580


No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for Latrunculin A

There are currently no reviews for this product. Be the first to review Latrunculin A and earn rewards!

Have you used Latrunculin A?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.