Latrunculin A

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Actin-related Products Small Molecule
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Description: Inhibitor of actin assembly and polymerization

Chemical Name: 4-[(1R,4Z,8E,10Z,12S,15R, 17R)-17-Hydroxy-5,12-dimethyl-3-oxo-2,16-dioxabicyclo[13.3.1]nonadeca-4,8,10-trien-17-yl)-2-thiazolidinone

Product Details
Citations (14)

Biological Activity

Reversible inhibitor of actin assembly; blocks actin adenine nucleotide exchange. Complexes with actin in vitro and interacts with actin monomers only, unlike cytochalasins. Prevents actin repolymerization into filaments and disrupts the actin cytoskeleton.

Technical Data

Soluble to 10 mM in DMSO
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Actin-latrunculin A structure and function.
    Yarmola et al.
    J.Biol.Chem., 2000;275:28120
  2. Latrunculin alters the actin-monomer subunit interface to prevent polymerization.
    Morton et al.
    Nat.Cell Biol., 2000;2:376
  3. On the chemistry of latrunculins A and B.
    Blasberger et al.
    Liebigs.Ann.Chem., 1989;1989:1171

Product Datasheets

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Citations for Latrunculin A

The citations listed below are publications that use Tocris products. Selected citations for Latrunculin A include:

14 Citations: Showing 1 - 10

  1. Matrix mechanical plasticity regulates cancer cell migration through confining microenvironments.
    Authors: Wisdom Et al.
    Nat Commun  2018;9:4144
  2. Cell-intrinsic and -extrinsic mechanisms promote cell-type-specific cytokinetic diversity.
    Authors: Davies Et al.
    Elife  2018;7
  3. Coordination of Receptor Tyrosine Kinase Signaling and Interfacial Tension Dynamics Drives Radial Intercalation and Tube Elongation.
    Authors: Neumann Et al.
    Dev Cell  2018;45:67
  4. Excitable Dynamics and Yap-Dependent Mechanical Cues Drive the Segmentation Clock.
    Authors: Hubaud Et al.
    Cell  2017;171:668
  5. Bronchoconstriction Induces TGF-β Release and Airway Remodelling in Guinea Pig Lung Slices.
    Authors: Oenema Et al.
    Oncotarget  2016;8:e65580
  6. The role of Rab6a and phosphorylation of non-muscle myosin IIA tailpiece in alcohol-induced Golgi disorganization.
    Authors: Petrosyan Et al.
    Sci Rep  2016;6:31962
  7. Regulation of actin dynamics by WNT-5A: implications for human airway smooth muscle contraction.
    Authors: Koopmans Et al.
    Sci Rep  2016;6:30676
  8. Macrophages redirect phagocytosis by non-professional phagocytes and influence inflammation
    Authors: Han Et al.
    Nature  2016;539:570
  9. Rapid dispersion of SynGAP from synaptic spines triggers AMPA receptor insertion and spine enlargement during LTP.
    Authors: Araki Et al.
    PLoS One  2015;85:173
  10. Spatiotemporal quantification of subcellular ATP levels in a single HeLa cell during changes in morphology.
    Authors: Suzuki Et al.
    Neuron  2015;5:16874


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