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Latrunculin B

Catalog #: 3974 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
3974/1
Latrunculin B | CAS No. 76343-94-7 | Actin-related Products
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Description: Inhibitor of actin polymerization

Chemical Name: (4R)-[(1R,4Z,8Z,10S,13R,15R)-15-hydroxy-5,10-dimethyl-3-oxo-2,14-dioxabicyclo[11.3.1]heptadeca-4,8-dien-15-yl]-2-thiazolidinone

Purity: ≥95%

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Biological Activity

Latrunculin B is an inhibitor of actin polymerization. Interacts with G-actin in a 1:1 ratio to inhibit polymerization into F-actin in vitro (IC50 values are ~60 and ~900 nM in absence and presence of calf serum, respectively). Marine toxin.

Technical Data

M.Wt:
395.51
Formula:
C20H29NO5S
Solubility:
Soluble to 50 mM in DMSO and to 50 mM in ethanol
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
76343-94-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Effects of cytochalasin D and latrunculin B on mechanical properties of cells.
    Wakatsuki et al.
    J.Cell.Sci., 2001;114:1025

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