Lavendustin A
Chemical Name: 5-[[(2,5-Dihydroxyphenyl)methyl][(2-hydroxyphenyl)methyl]amino]-2-hydroxybenzoic acid
Purity: ≥98%
Biological Activity
Lavendustin A is a potent, cell-permeable inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase (IC50 = 11 nM). Inhibits p60c-src with an IC50 of 500 nM and is selective over PKA, PKC and PI 3-kinase (IC50 > 100 μM).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Kinetic analysis of the inhibition of the epidermal growth factor receptor tyrosine kinase by lavendustin-A and its analogue.
Hsu et al.
J.Biol.Chem., 1991;266:21105 -
Isolation of a novel tyrosine kinase inhibitor, lavendustin A, from Streptomyces griseolavendus.
Onoda et al.
J.Nat.Prod., 1989;52:1252 -
Long-term potentiation in the hippocampus is blocked by tyrosine kinase inhibitors.
O'Dell et al.
Nature, 1991;353:558
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