Catalog Number: 1331
Alternate Names: RG 14355
Chemical Name: 5-[[(2,5-Dihydroxyphenyl)methyl][(2-hydroxyphenyl)methyl]amino]-2-hydroxybenzoic acid
Biological Activity
Potent, cell-permeable inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase (IC50 = 11 nM). Inhibits p60c-src with an IC50 of 500 nM and is selective over PKA, PKC and PI 3-kinase (IC50 > 100 μM).
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 25 mM in ethanol and to 25 mM in DMSO
  • Purity:
  • Storage:
    Desiccate at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Kinetic analysis of the inhibition of the epidermal growth factor receptor tyrosine kinase by lavendustin-A and its analogue.
    Hsu et al.
    J.Biol.Chem., 1991;266:21105
  2. Long-term potentiation in the hippocampus is blocked by tyrosine kinase inhibitors.
    O'Dell et al.
    Nature, 1991;353:558
  3. Isolation of a novel tyrosine kinase inhibitor, lavendustin A, from Streptomyces griseolavendus.
    Onoda et al.
    J.Nat.Prod., 1989;52:1252
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