Lavendustin A

Key Product Details

Product Description

Lavendustin A is a potent, cell-permeable inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase (IC₅₀ = 11 nM). Inhibits p60^c-src with an IC₅₀ of 500 nM and is selective over PKA, PKC and PI 3-kinase (IC₅₀ > 100 μM).

Product Specifications for Lavendustin A

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Lavendustin A

The following data is based on the product molecular weight 381.38.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

3 2 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	10.49 mL	52.44 mL	104.88 mL
1.25 mM	2.10 mL	10.49 mL	20.98 mL
2.5 mM	1.05 mL	5.24 mL	10.49 mL
12.5 mM	0.21 mL	1.05 mL	2.10 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• O'Dell Long-term potentiation in the hippocampus is blocked by tyrosine kinase inhibitors. Nature 1991 PMID: 1656271
• Onoda Isolation of a novel tyrosine kinase inhibitor, lavendustin A, from Streptomyces griseolavendus. J.Nat.Prod. 1989 PMID: 2614420
• Hsu Kinetic analysis of the inhibition of the epidermal growth factor receptor tyrosine kinase by lavendustin-A and its analogue. J.Biol.Chem. 1991 PMID: 1939153

Product Documents for Lavendustin A