Lazabemide hydrochloride

Key Product Details

Product Description

Lazabemide hydrochloride is a selective, reversible monoamine oxidase B (MAO-B) inhibitor (IC₅₀ values are 0.03 and > 100 μM for MAO-B and MAO-A respectively). Inhibits monoamine uptake at high concentrations (IC₅₀ values are 86, 123 and > 500 μM for noradrenalin, serotonin and dopamine uptake respectively).

Product Specifications for Lazabemide hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Lazabemide hydrochloride

The following data is based on the product molecular weight 236.10.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.24 mL	21.18 mL	42.35 mL
5 mM	0.85 mL	4.24 mL	8.47 mL
10 mM	0.42 mL	2.12 mL	4.24 mL
50 mM	0.08 mL	0.42 mL	0.85 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 3 publications citing the usage of this product.

• Bondiolotti In vitro effects on monoamine uptake and release by the reversible monoamine oxidase-B inhibitors lazabemide and N-(2-aminoethyl)-p-chlorobenzamide: a comparison with L-deprenyl. Biochem.Pharmacol. 1995 PMID: 7605351
• Guimaraes and Soares-da-Silva The activity of MAO A and B in rat renal cells and tubules. Life Sci. 1998 PMID: 9489509
• Saura Quantitative enzyme radioautography with ³H-Ro 41-1049 and ³H-Ro 19-6327 in vitro: localization and abundance of MAO-A and MAO-B in rat CNS, peripheral organs, and human brain. J.Neurosci. 1992 PMID: 1578281

Product Documents for Lazabemide hydrochloride