LCL 161, phenol

Name: LCL 161, phenol
Brand: Tocris Bioscience
SKU: 7178
Price: 668 USD
Availability: InStock

Tocris Bioscience | Catalog # 7178

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Product Documents

Functionalized IAP ligand for PROTACs

Technical Data
Reviews

Product Description
Product Specifications
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

Functionalized IAP ligand for PROTACs

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Product Description

LCL 161, phenol is a functionalized IAP (XIAP and cIAP) ligand for PROTAC^® research and development. Boc protected LCL 161. Supplied with a phenol functional handle for ready conjugation to a linker/target protein ligand. NanoBRET assays show EC₅₀ values of 7.5, 18.2 and 25.3 nM for cIAP1, XIAP and cIAP2 proteins, respectively. Part of a range of functionalized tool molecules for PROTAC R&D.

Please contact us for SD files of our available Degrader Building Blocks.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Usage Guidelines

This product is provided for use in onward chemistry. Suitable solvents can be used.

Product Specifications for LCL 161, phenol

Molecular Weight

598.76

Formula

C₃₁H₄₂N₄O₆S

Storage

Store at -20°C

Purity

≥95% (HPLC)

Chemical Name

tert-Butyl ((S)-1-(((S)-1-cyclohexyl-2-((S)-2-(4-(3-hydroxybenzoyl)thiazol-2-yl)pyrrolidin-1-yl)-2-oxoethyl)amino)-1-oxopropan-2-yl)(methyl)carbamate

CAS Number

2095244-42-9

InChI Key

SPXBMEKMIPOEMC-LQGLAIQGSA-N

SMILES

OC1=CC(C(C2=CSC([C@@H]3CCCN3C([C@H](C4CCCCC4)NC([C@@H](N(C(OC(C)(C)C)=O)C)C)=O)=O)=N2)=O)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Calculators

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Background References

References are publications that support the biological activity of the product.

Shimokawa Targeting the allosteric site of oncoprotein BCR-ABL as an alternative strategy for effective target protein degradation. ACS Med.Chem.Lett. 2017 PMID: 29057048
Schwalm A toolbox for the generation of chemical probes for baculovirus IAP repeat containing proteins. Front.Cell.Dev.Biol. 2022 PMID: 35721509
Ohoka In vivo knockdown of pathogenic proteins via specific and nongenetic inhibitor of apoptosis protein (IAP)-dependent protein erasers (SNIPERs). J.Biol.Chem. 2017 PMID: 28154167

Product Documents for LCL 161, phenol

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Download SDS

Product Specific Notices for LCL 161, phenol

For research use only

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