Catalog Number: 5082
Chemical Name: 3-[[(2-Methylphenyl)methyl]thio]-6-(2-pyridinyl)-pyridazine
Biological Activity
Increases expression of glutamate transporter EAAT2 in PA-EAAT2 cells. Displays neuroprotective activity in vivo. Shown to improve learning and memory, restore synaptic integrity and reduce amyloid plaque burden in APPSw/Ind mice.
Technical Data
  • M.Wt:
    293.39
  • Formula:
    C17H15N3S
  • Solubility:
    Soluble to 100 mM in DMSO and to 20 mM in ethanol
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    894002-50-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Glutamate transporter EAAT2: a new target for the treatment of neurodegenerative diseases.
    Lin et al.
    Future Med Chem, 2012;4:1689
  2. Structure-activity relationship study of pyridazine derivatives as glutamate transporter EAAT2 activators.
    Xing et al.
    Bioorg.Med.Chem.Lett., 2011;21:5774
  3. : Mechanism of LDN-212320 induction of glutamate transporter EAAT2 expression .
    Lin et al.
    Society for Neuroscience (Abstract), 2013;:99

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