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LDN 212320

Catalog #: 5082 Datasheet / COA / SDS

Discontinued Product

5082 has been discontinued.
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LDN 212320 | CAS No. 894002-50-7 | Glutamate (EAAT) Transporter Compounds
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Description: Increases EAAT2 expression; neuroprotective

Chemical Name: 3-[[(2-Methylphenyl)methyl]thio]-6-(2-pyridinyl)-pyridazine

Purity: ≥98%

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Biological Activity

LDN 212320 is a increases expression of glutamate transporter EAAT2 in PA-EAAT2 cells. Displays neuroprotective activity in vivo. Shown to improve learning and memory, restore synaptic integrity and reduce amyloid plaque burden in APPSw/Ind mice.

Technical Data

M.Wt:
293.39
Formula:
C17H15N3S
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
894002-50-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Glutamate transporter EAAT2: a new target for the treatment of neurodegenerative diseases.
    Lin et al.
    Future Med Chem, 2012;4:1689
  2. Structure-activity relationship study of pyridazine derivatives as glutamate transporter EAAT2 activators.
    Xing et al.
    Bioorg.Med.Chem.Lett., 2011;21:5774
  3. : Mechanism of LDN-212320 induction of glutamate transporter EAAT2 expression .
    Lin et al.
    Society for Neuroscience (Abstract), 2013;:99
  4. A small molecule modulator of glutamate transporter EAAT2 ameliorates Alzheimer�s-like pathologies and memory deficits in APPSw/Ind mice.
    Takahashi et al.
    Society for Neuroscience (Abstract), 2013;:103

Product Datasheets

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