Catalog Number: 4577
Biological Activity
Fluorescent ligand that binds to the α4β1 integrin (VLA-4) with high affinity (Kd values are 0.3 nM and 12 nM for binding to U937 cells in the presence and absence of Mn2+ respectively). Used to detect VLA-4 affinity and conformational changes.
Technical Data
  • M.Wt:
  • Formula:
  • Sequence:
    LDVPAAK (Modifications: Leu-1 N-2-[4-[[[(2-methylphenyl)amino]carbonyl]amino]phenyl]acetyl-, Lys-6 N-FITC conjugate)
  • Solubility:
    Soluble to 1 mg/ml in PBS (pH 7.4)
  • Storage:
    Store at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. FRET detection of cellular α4-integrin conformational activation.
    Chigaev et al.
    Biophys.J., 2003;85:3951
  2. Real time analysis of the affinity regulation of alpha 4-integrin. The physiologically activated receptor is intermediate in affinity between resting and Mn2+ or antibody activation.
    Chigaev et al.
    J.Biol.Chem., 2001;276:48670
  3. Conformational mAb as a tool for integrin ligand discovery.
    Njus et al.
    Assay Drug Dev.Technol., 2009;7:507
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