Leukadherin 1

Catalog # Availability Size / Price Qty
4921/10
4921/50
Cat.No. 4921 - Leukadherin 1 | C22H15NO4S2 | CAS No. 344897-95-6
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Description: Allosteric activator of CD11b/CD18

Chemical Name: 4-[(5-[[4-Oxo-3-(phenylmethyl)-2-thioxo-5-thiazolidinylidene]methyl]-2-furanyl]benzoic acid

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Biological Activity

Allosteric activator of CD11b/CD18. Increases CD11b/CD18-dependent cell adhesion to fibrinogen (EC50 = 4 μM). Decreases leukocyte motility and transendothelial migration; reduces inflammation. Also activates complement receptor 3 (CR3), and promotes CR3-dependent leukocyte adhesion to fibrinogen-coated surfaces.

Technical Data

Formula:
C22H15NO4S2
Solubility:
Soluble to 10 mM in DMSO with gentle warming
Storage:
Store the unopened product at 2 - 8 °C. Do not use past expiration date.
CAS No:
344897-95-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

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