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Leukadherin 1

4921 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4921/10
4921/50
Leukadherin 1 | CAS No. 344897-95-6 | Integrin Receptor Activators
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Description: Allosteric activator of CD11b/CD18

Chemical Name: 4-[(5-[[4-Oxo-3-(phenylmethyl)-2-thioxo-5-thiazolidinylidene]methyl]-2-furanyl]benzoic acid

Purity: ≥98%

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Biological Activity

Allosteric activator of CD11b/CD18. Increases CD11b/CD18-dependent cell adhesion to fibrinogen (EC50 = 4 μM). Decreases leukocyte motility and transendothelial migration; reduces inflammation. Also activates complement receptor 3 (CR3), and promotes CR3-dependent leukocyte adhesion to fibrinogen-coated surfaces.

Technical Data

M.Wt:
421.49
Formula:
C22H15NO4S2
Solubility:
Soluble to 10 mM in DMSO with gentle warming
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
344897-95-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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VersaClone cDNA Plasmids

Mouse CD11b/Integrin alpha M (NP_032427) VersaClone cDNA

RDC1740

Human Integrin beta 2/CD18 (NP_000202) VersaClone cDNA

RDC0398

Mouse Integrin beta 2/CD18 (NP_032430) VersaClone cDNA

RDC1476

Human CD11b/Integrin alpha M (NP_001139280) VersaClone cDNA

RDC0847

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