Chemical Name: 4-[(5-[[4-Oxo-3-(phenylmethyl)-2-thioxo-5-thiazolidinylidene]methyl]-2-furanyl]benzoic acid
Biological ActivityAllosteric activator of CD11b/CD18. Increases CD11b/CD18-dependent cell adhesion to fibrinogen (EC50 = 4 μM). Decreases leukocyte motility and transendothelial migration; reduces inflammation. Also activates complement receptor 3 (CR3), and promotes CR3-dependent leukocyte adhesion to fibrinogen-coated surfaces.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Small molecule-mediated activation of the integrin CD11b/CD18 reduces inflammatory disease.
Maiguel et al.
Complement receptor 3 influences Toll-like receptor 7/8-dependent inflammation.
Reed et al.
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