Leukadherin 1
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Description: Allosteric activator of CD11b/CD18
Chemical Name: 4-[(5-[[4-Oxo-3-(phenylmethyl)-2-thioxo-5-thiazolidinylidene]methyl]-2-furanyl]benzoic acid
Purity: ≥98%
Biological Activity
Allosteric activator of CD11b/CD18. Increases CD11b/CD18-dependent cell adhesion to fibrinogen (EC50 = 4 μM). Decreases leukocyte motility and transendothelial migration; reduces inflammation. Also activates complement receptor 3 (CR3), and promotes CR3-dependent leukocyte adhesion to fibrinogen-coated surfaces.Technical Data
M.Wt:
421.49
Formula:
C22H15NO4S2
Solubility:
Soluble to 10 mM in DMSO with gentle warming
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
344897-95-6
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
Small molecule-mediated activation of the integrin CD11b/CD18 reduces inflammatory disease.
Maiguel et al.
Sci.Signal., 2011;4:1 -
Complement receptor 3 influences Toll-like receptor 7/8-dependent inflammation.
Reed et al.
J.Biol.Chem., 2013;288:9077
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