Leukadherin 1

Key Product Details

Product Description

Leukadherin 1 is an allosteric activator of CD11b/CD18. Increases CD11b/CD18-dependent cell adhesion to fibrinogen (EC₅₀ = 4 μM). Decreases leukocyte motility and transendothelial migration; reduces inflammation. Also activates complement receptor 3 (CR3), and promotes CR3-dependent leukocyte adhesion to fibrinogen-coated surfaces.

Product Specifications for Leukadherin 1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Leukadherin 1

The following data is based on the product molecular weight 421.49.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	23.73 mL	118.63 mL	237.25 mL
0.5 mM	4.75 mL	23.73 mL	47.45 mL
1 mM	2.37 mL	11.86 mL	23.73 mL
5 mM	0.47 mL	2.37 mL	4.75 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Reed Complement receptor 3 influences Toll-like receptor 7/8-dependent inflammation. J.Biol.Chem. 2013 PMID: 23386618
• Maiguel Small molecule-mediated activation of the integrin CD11b/CD18 reduces inflammatory disease. Sci.Signal. 2011 PMID: 21900205

Product Documents for Leukadherin 1