Allosteric activator of CD11b/CD18. Increases CD11b/CD18-dependent cell adhesion to fibrinogen (EC50
= 4 μ
M). Decreases leukocyte motility and transendothelial migration; reduces inflammation. Also activates complement receptor 3 (CR3), and promotes CR3-dependent leukocyte adhesion to fibrinogen-coated surfaces.
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Small molecule-mediated activation of the integrin CD11b/CD18 reduces inflammatory disease.
Maiguel et al.
Complement receptor 3 influences Toll-like receptor 7/8-dependent inflammation.
Reed et al.