Leupeptin hemisulfate

Tocris Bioscience | Catalog # 1167

Inhibits trypsin-like/cysteine proteases
Tocris Bioscience

Key Product Details

Description

Inhibits trypsin-like/cysteine proteases
View all Additional Synthetic Protease Inhibitors »

Product Description

Leupeptin hemisulfate is a reversible inhibitor of trypsin-like and cysteine proteases such as calpain. Shown to inhibit activation-induced programmed cell death.

Product Specifications for Leupeptin hemisulfate

Molecular Weight

475.60

Formula

C20H38N6O4.½H2SO4

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

103476-89-7

PubChem ID

2733491

InChI Key

CIPMKIHUGVGQTG-VFFZMTJFSA-N

SMILES

OS(O)(=O)=O.[H]C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O.[H]C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solubility Soluble to 10mg/ml in water

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 30 publications citing the usage of this product.

Product Documents for Leupeptin hemisulfate

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Leupeptin hemisulfate

For research use only

Citations for Leupeptin hemisulfate

Customer Reviews for Leupeptin hemisulfate (4)

4.5 out of 5
4 Customer Ratings
5 Stars
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Showing  1 - 4 of 4 reviews Showing All
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  • Leupeptin hemisulfate
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: HCT116
    Verified Customer | Posted 01/28/2025
    Protease inhibition in cell lysates 2 mM, samples subjected to Western Blot
    Leupeptin hemisulfate 1167
  • Happy with results
    Name: Estela Correa
    Species: Mouse
    Assay Type: Ex Vivo
    Verified Customer | Posted 07/27/2022
    Be careful when measuring weight. Very light material.
    I used it as a protease inhibitor. Concentration of 1:1000.
  • Protease Inhibitor
    Name: Anonymous
    Species: Rat
    Assay Type: In Vitro
    Cell Line/Tissue: Vessels
    Verified Customer | Posted 03/08/2021
    I have used this product as the protease inhibitor in my protein isolation cocktail mix.
  • effective protease inhibitor
    Name: Anonymous
    Assay Type: In Vitro
    Verified Customer | Posted 05/30/2018
    We used Leupeptin hemisulfate as a protease inhibitor to restore surface antigen in cell suspension cultures. We've used it both in vitro and in vivo.

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