Biological ActivityReversible inhibitor of trypsin-like and cysteine proteases such as calpain. Shown to inhibit activation-induced programmed cell death.
(Modifications: Leu-1 = N-terminal Ac, Arg-3 = Arginal)
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Cell-penetrating inhibitors of calpain.
Inhibition of activation-induced programmed cell death and restoration of defective immune responses of HIV+ donors by cysteine protease inhibitors.
Sarin et al.
Developing selective inhibitors of calpain.
Citations for Leupeptin hemisulfate
The citations listed below are publications that use Tocris products. Selected citations for Leupeptin hemisulfate include:
2 Citations: Showing 1 - 2
Proteolytic and Opportunistic Breaching of the Basement Membrane Zone by Immune Cells during Tumor Initiation.
Authors: Berg Et al.
Cell Rep 2019;27:2837
Ubiquitination and proteasomal degradation of ATG12 regulates its proapoptotic activity.
Authors: Haller Et al.
J Pharmacol Exp Ther 2015;10:2269
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We used Leupeptin hemisulfate as a protease inhibitor to restore surface antigen in cell suspension cultures. We've used it both in vitro and in vivo.