Leupeptin hemisulfate

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Leupeptin hemisulfate
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Description: Inhibits trypsin-like/cysteine proteases

Purity: ≥95%

Product Details
Citations (2)
Reviews (2)

Biological Activity

Leupeptin hemisulfate is a reversible inhibitor of trypsin-like and cysteine proteases such as calpain. Shown to inhibit activation-induced programmed cell death.

Technical Data


(Modifications: Leu-1 = N-terminal Ac, Arg-3 = Arginal)

Soluble to 10 mg/ml in water
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Other Product-Specific Information:
  • This peptide is supplied in gross weight.

Background References

  1. An autocrine/paracrine circuit of growth differentiation factor (GDF) 15 has a role for maintenance of breast cancer stem-like cells
    A Sasahara, K Tominaga, T Nishimura, M Yano, E Kiyokawa, M Noguchi, M Noguchi, H Kanauchi, T Ogawa, H Minato, K Tada, Y Seto, A Tojo, N Gotoh
    Oncotarget, 2017;8(15):24869-24881.
  2. LOXL2 status correlates with tumor stage and regulates integrin levels to promote tumor progression in ccRCC.
    Hase H, Jingushi K, Ueda Y, Kitae K, Egawa H, Ohshio I, Kawakami R, Kashiwagi Y, Tsukada Y, Kobayashi T, Nakata W, Fujita K, Uemura M, Nonomura N, Tsujikawa K
    Mol Cancer Res, 2014;12(12):1807-17.
  3. Cell-penetrating inhibitors of calpain.
    TiBS, 1991;16:150
  4. Inhibition of activation-induced programmed cell death and restoration of defective immune responses of HIV+ donors by cysteine protease inhibitors.
    Sarin et al.
    J.Immunol., 1994;153:862
  5. Developing selective inhibitors of calpain.
    TiPS, 1990;11:139

Product Datasheets

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Citations for Leupeptin hemisulfate

The citations listed below are publications that use Tocris products. Selected citations for Leupeptin hemisulfate include:

2 Citations: Showing 1 - 2


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Reviews for Leupeptin hemisulfate

Average Rating: 4 (Based on 2 Reviews)

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Protease Inhibitor
By Anonymous on 03/08/2021
Species: Rat

I have used this product as the protease inhibitor in my protein isolation cocktail mix.

effective protease inhibitor
By Anonymous on 05/30/2018

We used Leupeptin hemisulfate as a protease inhibitor to restore surface antigen in cell suspension cultures. We've used it both in vitro and in vivo.

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