Chemical Name: 6-[1-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)cyclopropyl]-3-pyridinecarboxylic acid
Biological ActivityLG 100268 is a potent and selective retinoid X receptor (RXR) agonist (EC50 = 4 nM). Displays >1000-fold selectivity for RXR over RAR. Activates RXR homodimers to induce transcriptional activation. Induces tissue transglutaminase (TGase) activity in HL-60 human promyelocytic leukemia cell line. Also activates RXR/PPARγ heterodimers.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Activation of specific RXR heterodimers by an antagonist of RXR homodimers.
Lala et al.
Design and synthesis of potent retinoid X receptor selective ligands that induce apoptosis in leukemia cells.
Boehm et al.
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