LG 100268

Key Product Details

Product Description

LG 100268 is a potent and selective retinoid X receptor (RXR) agonist (EC₅₀ = 4 nM). Displays >1000-fold selectivity for RXR over RAR. Activates RXR homodimers to induce transcriptional activation. Induces tissue transglutaminase (TGase) activity in HL-60 human promyelocytic leukemia cell line. Also activates RXR/PPARγ heterodimers.

Product Specifications for LG 100268

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for LG 100268

The following data is based on the product molecular weight 363.49.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	5.50 mL	27.51 mL	55.02 mL
2.5 mM	1.10 mL	5.50 mL	11.00 mL
5 mM	0.55 mL	2.75 mL	5.50 mL
25 mM	0.11 mL	0.55 mL	1.10 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Boehm Design and synthesis of potent retinoid X receptor selective ligands that induce apoptosis in leukemia cells. J.Med.Chem. 1995 PMID: 7636877
• Lala Activation of specific RXR heterodimers by an antagonist of RXR homodimers. Nature. 1996 PMID: 8837780

Product Documents for LG 100268