Potent LIM kinase inhibitor (IC50
values are 7 and 8 nM for LIMK1 and LIMK2 respectively). Inhibits cofilin phosphorylation in MDA-MB-231 breast cancer cells. Reduces MDA-MB-231 tumor cell invasion in a 3D matrigel invasion assay.
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All Tocris products are intended for laboratory research use only.
The actin-severing protein cofilin is downstream of neuregulin signaling and is essential for schwann cell myelination.
Sparrow N, Manetti ME, Bott M, Fabianac T, Petrilli A, Bates ML, Bunge MB, Lambert S, Fernandez-Valle C.
Identification of a nonkinase target mediating cytotoxicity of novel kinase inhibitors.
Ross-Macdonald et al.
Mol.Cancer Ther., 2008;7:3490
LIM kinases are required for invasive path generation by tumor and tumor-associated stromal cells.
Scott et al.
J.Cell Biol., 2010;191:169