Catalog Number: 4745
Alternate Names: BMS 5
Chemical Name: N-[5-[1-(2,6-Dichlorophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]-2-thiazolyl]-2-methylpropanamide
Biological Activity
Potent LIM kinase inhibitor (IC50 values are 7 and 8 nM for LIMK1 and LIMK2 respectively). Inhibits cofilin phosphorylation in MDA-MB-231 breast cancer cells. Reduces MDA-MB-231 tumor cell invasion in a 3D matrigel invasion assay.
Technical Data
  • M.Wt:
    431.29
  • Formula:
    C17H14Cl2F2N4OS
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    1338247-35-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. The actin-severing protein cofilin is downstream of neuregulin signaling and is essential for schwann cell myelination.
    Sparrow N, Manetti ME, Bott M, Fabianac T, Petrilli A, Bates ML, Bunge MB, Lambert S, Fernandez-Valle C.
    J Neurosci;32(15):5284-97.
  2. Identification of a nonkinase target mediating cytotoxicity of novel kinase inhibitors.
    Ross-Macdonald et al.
    Mol.Cancer Ther., 2008;7:3490
  3. LIM kinases are required for invasive path generation by tumor and tumor-associated stromal cells.
    Scott et al.
    J.Cell Biol., 2010;191:169

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