Catalog Number: 6068
Chemical Name: N-Methyl-N-[3-(3-methyl-1,2,4-triazolo[4,3-b]pyridazin-6-yl)phenyl]acetamide
Biological Activity
RNA binding protein Lin28 inhibitor (IC50 = 8 μM). Blocks binding of Lin28 to let-7 pre-micro RNA. Inhibits stemness and induces differentiation of murine ESCs. Inhibits growth of tumor cell lines and tumor-sphere formation in vitro. Also bromodomain inhibitor.
Technical Data
  • M.Wt:
    281.31
  • Formula:
    C15H15N5O
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    108825-65-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. A small-molecule inhibitor of Lin28.
    Roos et al.
    ACS Chem.Biol., 2016;11:2773
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