Lin28 1632

Catalog # Availability Size / Price Qty
6068/10
6068/50
Lin28 1632 | CAS No. 108825-65-6 | DNA, RNA and Protein Synthesis Inhibitors
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Description: RNA binding protein Lin28 inhibitor; promotes mESC differentiation; also bromodomain inhibitor

Chemical Name: N-Methyl-N-[3-(3-methyl-1,2,4-triazolo[4,3-b]pyridazin-6-yl)phenyl]acetamide

Purity: ≥98%

Product Details
Reviews (1)

Biological Activity

Lin28 1632 is an RNA binding protein Lin28 inhibitor (IC50 = 8 μM). Lin28 1632 blocks binding of Lin28 to let-7 pre-micro RNA. Lin28 1632 inhibits stemness and induces differentiation of murine ESCs. Lin28 1632 increases let-7 miRNA and suppresses PD-L1 expression in multiple human cancer cell lines. Lin28 1632 inhibits growth of tumor cell lines and tumor-sphere formation in vitro. Lin28 1632 also inhibits growth of tumor xenografts in mice by enhancing T cell-mediated antitumor immunity. Lin28 1632 is also bromodomain inhibitor. Lin28 1632 inhibits tumor growth and metastasis in vivo in immunodeficient orthotopic mouse models of human breast cancer cell MDA-MB-231.

Technical Data

M.Wt:
281.31
Formula:
C15H15N5O
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
108825-65-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. A small-molecule inhibitor of Lin28.
    Roos et al.
    ACS Chem.Biol., 2016;11:2773
  2. LIN28/ let-7/PD-L1 pathway as a target for cancer immunotherapy.
    Chen et al.
    Cancer Immunol.Res., 2019;7:487

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Good inhibitor for Lin28
By Satbir Thakur on 05/17/2021
Application: Species: Human

Used as an inhibitor for Lin28 for 96 h in cell lines expressing Lin28. The protein level was then estimated using a western blot method.

PMID: 33506207 Reference

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