Liproxstatin-1 hydrochloride

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Liproxstatin-1 hydrochloride | Additional Apoptosis-related Compounds
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Description: Potent ferroptosis inhibitor

Chemical Name: N-[(3-Chlorophenyl)methyl]spiro[piperidine-4,2'(1'H)-quinoxalin]-3'-amine hydrochloride

Purity: ≥98%

Product Details

Biological Activity

Potent ferroptosis inhibitor (IC50 = 22 nM). Protects human renal proximal tubule cells from 1S,3R-RSL3 (Cat.No. 6118) -induced cell death in vitro. Inhibits acute renal failure and prolongs survival in Gpx4 knockdown mice. Also mitigates tissue damage in an in vivo hepatic ischemia/reperfusion model.

Technical Data

Soluble to 100 mM in DMSO
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice.
    Friedmann Angeli et al.
    Nat.Cell.Biol., 2014;16:1180

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