Liproxstatin-1 hydrochloride

Key Product Details

Product Description

Liproxstatin-1 hydrochloride is a potent ferroptosis inhibitor (IC₅₀ = 22 nM). Protects human renal proximal tubule cells from 1S,3R-RSL3 (Cat.No. 6118) -induced cell death in vitro. Inhibits acute renal failure and prolongs survival in Gpx4 knockdown mice. Also mitigates tissue damage in an in vivo hepatic ischemia/reperfusion model.

Product Specifications for Liproxstatin-1 hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Liproxstatin-1 hydrochloride

The following data is based on the product molecular weight 377.31.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.65 mL	13.25 mL	26.50 mL
5 mM	0.53 mL	2.65 mL	5.30 mL
10 mM	0.27 mL	1.33 mL	2.65 mL
50 mM	0.05 mL	0.27 mL	0.53 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 6 publications citing the usage of this product.

• Friedmann Angeli Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice. Nat.Cell.Biol. 2014 PMID: 25402683

Product Documents for Liproxstatin-1 hydrochloride