Chemical Name: N-[(3-Chlorophenyl)methyl]spiro[piperidine-4,2'(1'H)-quinoxalin]-3'-amine hydrochloride
Biological ActivityPotent ferroptosis inhibitor (IC50 = 22 nM). Protects human renal proximal tubule cells from 1S,3R-RSL3 (Cat.No. 6118) -induced cell death in vitro. Inhibits acute renal failure and prolongs survival in Gpx4 knockdown mice. Also mitigates tissue damage in an in vivo hepatic ischemia/reperfusion model.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice.
Friedmann Angeli et al.
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