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Lithium carbonate

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Lithium carbonate | CAS No. 554-13-2 | Na+/K+ ATPase Inhibitors
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Description: Mood stabilizer; inhibits GSK-3 in vivo

Chemical Name: Carbonic acid dilithium salt

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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Lithium carbonate is a mood stabilizer; thought to act by reducing catecholamine neurotransmitter concentration, through an effect on the Na+/K+ ATPase pump. Effective in the treatment of bipolar disorder. Inhibits GSK-3 in vivo.

Technical Data

M.Wt:
73.89
Formula:
Li2CO3
Solubility:
Soluble to 100 mM in water
Storage:
Store at RT
CAS No:
554-13-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Overview of the mechanism of action of Li in the brain: fifty-year update.
    Lenox and Hahn
    J.Clin.Psychiatry, 2000;61:5
  2. In vivo evidence in the brain for Li inhibition of glycogen synthase kinase-3.
    Gould et al.
    Neuropsychopharmacology, 2004;29:32

Product Datasheets

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⚠ WARNING: This product can expose you to chemicals including Lithium carbonate, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov

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Li2CO3 prolongs cardiac action potential duration
By Chintan Koyani on 10/23/2018
Application: Species: Other

Guinea pig ventricular cardiomyocytes were patched and stimulated at a 1 Hz frequency to record action potentials before and after Li2CO3 (10 and 30 µM). Li2CO3 significantly prolonged action potential duration at 20% and 90% repolarization levels.

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