Chemical Name: Carbonic acid dilithium salt
Biological ActivityMood stabilizer; thought to act by reducing catecholamine neurotransmitter concentration, through an effect on the Na+/K+ ATPase pump. Effective in the treatment of bipolar disorder. Inhibits GSK-3 in vivo.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Overview of the mechanism of action of Li in the brain: fifty-year update.
Lenox and Hahn
In vivo evidence in the brain for Li inhibition of glycogen synthase kinase-3.
Gould et al.
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Guinea pig ventricular cardiomyocytes were patched and stimulated at a 1 Hz frequency to record action potentials before and after Li2CO3 (10 and 30 µM). Li2CO3 significantly prolonged action potential duration at 20% and 90% repolarization levels.