LM 10

Key Product Details

Product Description

LM 10 is a selective tryptophan 2,3-dioxygenase (TDO) inhibitor (IC₅₀ values are 0.62 and 2 μM for human and mouse TDO, respectively). Exhibits selectivity for TDO over IDO, MAO-A, MAO-B, and a panel of receptors and transporters. Reduces growth of TDO-expressing P815 mastocytoma tumors in mice. Orally bioavailable.

Product Specifications for LM 10

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for LM 10

The following data is based on the product molecular weight 229.21.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.36 mL	21.81 mL	43.63 mL
5 mM	0.87 mL	4.36 mL	8.73 mL
10 mM	0.44 mL	2.18 mL	4.36 mL
50 mM	0.09 mL	0.44 mL	0.87 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Dolusić Tryptophan 2,3-dioxygenase (TDO) inhibitors. 3-(2-(pyridyl)ethenyl)indoles as potential anticancer immunomodulators. J.Med.Chem. 2011 PMID: 21726069
• Pilotte Reversal of tumoral immune resistance by inhibition of tryptophan 2,3-dioxygenase. Proc.Natl.Acad.Sci.U.S.A. 2012 PMID: 22308364

Product Documents for LM 10