LM 10

Catalog # Availability Size / Price Qty
5794/50
5794/10
Cat.No. 5794 - LM 10 | C11H8FN5 | CAS No. 1316695-35-8
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Description: Selective tryptophan 2,3-dioxygenase (TDO) inhibitor

Chemical Name: 6-Fluoro-3-[(1E)-2-(2H-tetrazol-5-yl)ethenyl]-1H-indole

Purity: ≥98%

Product Details
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Biological Activity

Selective tryptophan 2,3-dioxygenase (TDO) inhibitor (IC50 values are 0.62 and 2 μM for human and mouse TDO, respectively). Exhibits selectivity for TDO over IDO, MAO-A, MAO-B, and a panel of receptors and transporters. Reduces growth of TDO-expressing P815 mastocytoma tumors in mice. Orally bioavailable.

Technical Data

M.Wt:
229.21
Formula:
C11H8FN5
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol with gentle warming
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1316695-35-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

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