Chemical Name: N,N',N''Tris(2-hydroxyethyl)-1,3,5-benzenetricarboxamide
Biological ActivityLM 22A4 is a potent tropomyosin-related kinase B (TrkB) agonist. Induces activation of Trk, Akt and ERK in mouse hippocampus and striatum and exhibits neurotrophic activity. Reverses deficits in motor task learning in mice following traumatic brain injury; restores respiratory function in a rat model of Rett syndrome.
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A TrkB small molecule partial agonist rescues TrkB phosphorylation deficits and improves respiratory function in a mouse model of Rett syndrome.
Schmid et al.
Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents.
Massa et al.
Citations for LM 22A4
The citations listed below are publications that use Tocris products. Selected citations for LM 22A4 include:
2 Citations: Showing 1 - 2
Huntington's Disease Patient-Derived Astrocytes Display Electrophysiological Impairments and Reduced Neuronal Support.
Authors: Garcia Et al.
Front Neurosci 2019;13:669
Brain-derived neurotrophic factor enhances cholinergic contraction of longitudinal muscle of rabbit intestine via activation of phospholipase C.
Authors: Al-Qudah Et al.
Am J Physiol Gastrointest Liver Physiol 2014;306:G328
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