LM 22A4 (CAS 37988-18-4): R&D Systems
Catalog Number: 4607
Chemical Name: N,N',N''Tris(2-hydroxyethyl)-1,3,5-benzenetricarboxamide
Biological Activity
Potent tropomyosin-related kinase B (TrkB) agonist (IC50 = 47 nM). Induces activation of Trk, Akt and ERK in mouse hippocampus and striatum. Reverses deficits in motor task learning in mice following traumatic brain injury; restores respiratory function in a rat model of Rett syndrome.
Technical Data
  • M.Wt:
    339.34
  • Formula:
    C15H21N3O6
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in water
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    37988-18-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents.
    Massa et al.
    J.Clin.Invest., 2010;120:1774
  2. A TrkB small molecule partial agonist rescues TrkB phosphorylation deficits and improves respiratory function in a mouse model of Rett syndrome.
    Schmid et al.
    J.Neurosci., 2012;32:1803
Citations:

The citations listed below are publications that use Tocris products. Selected citations for LM 22A4 include:

1 Citations: Showing 1 - 1

  1. Brain-derived neurotrophic factor enhances cholinergic contraction of longitudinal muscle of rabbit intestine via activation of phospholipase C.
    Authors: Al-Qudah Et al.
    Am J Physiol Gastrointest Liver Physiol 2014;306:G328

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