Potent tropomyosin-related kinase B (TrkB) agonist (IC50
= 47 nM). Induces activation of Trk, Akt and ERK in mouse hippocampus and striatum. Reverses deficits in motor task learning in mice following traumatic brain injury; restores respiratory function in a rat model of Rett syndrome.
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Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents.
Massa et al.
A TrkB small molecule partial agonist rescues TrkB phosphorylation deficits and improves respiratory function in a mouse model of Rett syndrome.
Schmid et al.
The citations listed below are publications that use Tocris products. Selected citations for LM 22A4 include:
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