LM22B 10

Catalog # Availability Size / Price Qty
6037/50
6037/10
Cat.No. 6037 - LM22B 10 | C27H33ClN2O4 | CAS No. 342777-54-2
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Description: TrkB and TrkC agonist; brain penetrant

Chemical Name: 2,2',2',2'''-[[(4-Chlorophenyl)methylene]bis(4,1-phenylenenitrilo)]tetrakisethanol

Purity: ≥98%

Product Details
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Biological Activity

TrkB and TrkC agonist. Exhibits neurotrophic activity (EC50 = 200-300 nM), improves survival and increases neurite outgrowth in hippocampal cells in vitro. Exhibits no significant activity in a screen of 57 other receptors and transporters. Inhibits binding of BDNF and neurotrophin-3 to TrkB and TrkC, respectively. Active in vivo and brain penetrant.

Technical Data

M.Wt:
485.02
Formula:
C27H33ClN2O4
Solubility:
Soluble to 100 mM in DMSO and to 10 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
342777-54-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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