Chemical Name: 2,2',2',2'''-[[(4-Chlorophenyl)methylene]bis(4,1-phenylenenitrilo)]tetrakisethanol
Biological ActivityLM22B 10 is a TrkB and TrkC agonist. Exhibits neurotrophic activity (EC50 = 200-300 nM), improves survival and increases neurite outgrowth in hippocampal cells in vitro. Exhibits no significant activity in a screen of 57 other receptors and transporters. Inhibits binding of BDNF and neurotrophin-3 to TrkB and TrkC, respectively. Active in vivo and brain penetrant.
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Complete Your Research
A small molecule TrkB/TrkC neurotrophin receptor co-activator with distinctive effects on neuronal survival and process outgrowth.
Yang T, Massa SM, Tran KC et al.
Citation for LM22B 10
The citations listed below are publications that use Tocris products. Selected citations for LM22B 10 include:
1 Citation: Showing 1 - 1
Neurotrophin receptor activation rescues cognitive and synaptic abnormalities caused by hemizygosity of the psychiatric risk gene Cacna1c.
Authors: Tigaret Et al.
Mol Psychiatry 2021;26:1748
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