LMK 235

Tocris Bioscience | Catalog # 4830

Selective HDAC4/HDAC5 inhibitor
Tocris Bioscience
Discontinued Product
4830 has been discontinued. View all Class II Histone Deacetylases Inhibitors products.

Key Product Details

Description

Selective HDAC4/HDAC5 inhibitor
View all Class II Histone Deacetylases Inhibitors »

Product Description

LMK 235 is a selective histone deacetylase (HDAC) 4 and HDAC5 inhibitor (IC50 values are 4.22, 11.9, 55.7, 320, 852, 881, and 1278 nM for HDAC 5, 4, 6, 1, 11, 2, and 8, respectively). Demonstrates activity against chemoresistant cancer cell lines in an MTT assay for cytotoxicity using human ovarian cancer cell lines A2780 and cisplatin resistant A2780CisR (IC50 = 0.49 and 0.32 μM respectively).

Product Specifications for LMK 235

Molecular Weight

294.35

Formula

C15H22N2O4

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

N-[[6-(Hydroxyamino)-6-oxohexyl]oxy]-3,5-dimethylbenzamide

CAS Number

1418033-25-6

PubChem ID

71520717

InChI Key

VRYZCEONIWEUAV-UHFFFAOYSA-N

SMILES

CC1=CC(C(NOCCCCCC(NO)=O)=O)=CC(C)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 29.43 100
Ethanol 29.43 100

Preparing Stock Solutions for LMK 235

The following data is based on the product molecular weight 294.35.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.40 mL 16.99 mL 33.97 mL
5 mM 0.68 mL 3.40 mL 6.79 mL
10 mM 0.34 mL 1.70 mL 3.40 mL
50 mM 0.07 mL 0.34 mL 0.68 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 9 publications citing the usage of this product.

Product Documents for LMK 235

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for LMK 235

For research use only

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