Home / Class II Histone Deacetylases Inhibitors / LMK 235

LMK 235

Catalog #: 4830
4 Citations Datasheet / COA / SDS

Discontinued Product

4830 has been discontinued.
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LMK 235 | CAS No. 1418033-25-6 | Class II Histone Deacetylases Inhibitors
1 Image
Description: Selective HDAC4/HDAC5 inhibitor

Chemical Name: N-[[6-(Hydroxyamino)-6-oxohexyl]oxy]-3,5-dimethylbenzamide

Purity: ≥98%

Product Details
Citations (4)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

LMK 235 is a selective histone deacetylase (HDAC) 4 and HDAC5 inhibitor (IC50 values are 4.22, 11.9, 55.7, 320, 852, 881, and 1278 nM for HDAC 5, 4, 6, 1, 11, 2, and 8, respectively). Demonstrates activity against chemoresistant cancer cell lines in an MTT assay for cytotoxicity using human ovarian cancer cell lines A2780 and cisplatin resistant A2780CisR (IC50 = 0.49 and 0.32 μM respectively).

Technical Data

M.Wt:
294.35
Formula:
C15H22N2O4
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1418033-25-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Citations for LMK 235

The citations listed below are publications that use Tocris products. Selected citations for LMK 235 include:

4 Citations: Showing 1 - 4

  1. Polypharmacological Perturbation of the 14-3-3 Adaptor Protein Interactome Stimulates Neurite Outgrowth.
    Authors: Alyson E Et al.
    Cell Chem Biol  2020;27:657-667.e6
  2. Compounds targeting class II histone deacetylases do not cause panHDACI-associated impairment of megakaryocyte differentiation.
    Authors: Nianli Et al.
    Exp Hematol  2019;72:36-46
  3. Histone deacetylase 4 promotes type I IF. signaling, restricts DNA viruses, and is degraded via vaccinia virus protein C6.
    Authors: Lu Et al.
    Proc Natl Acad Sci U S A  2019;
  4. AMPK-HDAC5 pathway facilitates nuclear accumulation of HIF-1α and functional activation of HIF-1 by deacetylating Hsp70 in the cytosol.
    Authors: Chen Et al.
    Cell Cycle  2015;14:2520

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