LMK 235

Catalog # Availability Size / Price Qty
4830/10
4830/50
Cat.No. 4830 - LMK 235 | C15H22N2O4 | CAS No. 1418033-25-6
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Description: Selective HDAC4/HDAC5 inhibitor

Chemical Name: N-[[6-(Hydroxyamino)-6-oxohexyl]oxy]-3,5-dimethylbenzamide

Product Details
Citations (1)
Reviews

Biological Activity

Selective histone deacetylase (HDAC) 4 and HDAC5 inhibitor (IC50 values are 4.22, 11.9, 55.7, 320, 852, 881, and 1278 nM for HDAC 5, 4, 6, 1, 11, 2, and 8, respectively). Demonstrates activity against chemoresistant cancer cell lines in an MTT assay for cytotoxicity using human ovarian cancer cell lines A2780 and cisplatin resistant A2780CisR (IC50 = 0.49 and 0.32 μM respectively).

Technical Data

Formula:
C15H22N2O4
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Storage:
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
CAS No:
1418033-25-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

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Citation for LMK 235

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