Lofepramine

Key Product Details

Product Description

Lofepramine is a serotonin and noradrenalin re-uptake inhibitor (SNRI) that is metabolized to desipramine. Produces inhibition of liver tryptophan pyrollase activity in vitro and displays antidepressant properties in vivo.

Product Specifications for Lofepramine

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Lofepramine

The following data is based on the product molecular weight 418.97.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.75 mM	3.18 mL	15.91 mL	31.82 mL
3.75 mM	0.64 mL	3.18 mL	6.36 mL
7.5 mM	0.32 mL	1.59 mL	3.18 mL
37.5 mM	0.06 mL	0.32 mL	0.64 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Badawy The effects of lofepramine and desmethylimipramine on tryptophan metabolism and disposition in the rat Biochem.Pharmacol. 1991 PMID: 1867646
• Kelly and Leonard An investigation of the antidepressant properties of lofepramine and its desmethylated metabolites in the forced swim and olfactory bulbectomized rat models of depression. Eur.Neuropsychopharmacol. 1999 PMID: 10082234
• Leonard A comparison of the pharmacological properties of the novel tricyclic antidepressant lofepramine with its major metabolite, desipramine: a review. Int.Clin.Psychopharmacol. 1987 PMID: 2891742

Product Documents for Lofepramine