Catalog Number: 2545
Alternate Names: Lopramine, Leo 640
Chemical Name: 1-(4-Chlorophenyl)-2-[[3-(10,11-dihydro-5H-dibenz(Z)[b,f]azepin-5-yl)propyl]methylamino]ethanone
Biological Activity
Serotonin and noradrenalin re-uptake inhibitor (SNRI) that is metabolized to desipramine. Produces inhibition of liver tryptophan pyrollase activity in vitro and displays antidepressant properties in vivo.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 75 mM in DMSO and to 10 mM in ethanol
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. A comparison of the pharmacological properties of the novel tricyclic antidepressant lofepramine with its major metabolite, desipramine: a review.
    Int.Clin.Psychopharmacol., 1987;2:281
  2. The effects of lofepramine and desmethylimipramine on tryptophan metabolism and disposition in the rat
    Badawy et al.
    Biochem.Pharmacol., 1991;42:921
  3. An investigation of the antidepressant properties of lofepramine and its desmethylated metabolites in the forced swim and olfactory bulbectomized rat models of depression.
    Kelly and Leonard
    Eur.Neuropsychopharmacol., 1999;9:101
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