Serotonin and noradrenalin re-uptake inhibitor (SNRI) that is metabolized to desipramine. Produces inhibition of liver tryptophan pyrollase activity in vitro
and displays antidepressant properties in vivo
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All Tocris products are intended for laboratory research use only.
A comparison of the pharmacological properties of the novel tricyclic antidepressant lofepramine with its major metabolite, desipramine: a review.
The effects of lofepramine and desmethylimipramine on tryptophan metabolism and disposition in the rat
Badawy et al.
An investigation of the antidepressant properties of lofepramine and its desmethylated metabolites in the forced swim and olfactory bulbectomized rat models of depression.
Kelly and Leonard