Chemical Name: 1-[(2,4-Dichlorophenyl)methyl]-1H-indazole-3-carboxylic acid
Biological ActivityLonidamine is an anticancer and antispermatogenic agent in vitro and in vivo. Inhibits cellular energy metabolism in some cells via inhibition of mitochondrial hexokinase. Also blocks CFTR Cl- channels in vitro.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Effects of lonidamine on murine and human tumor cells in vitro. A morphological and biochemical study.
De Martino et al.
Mechanism of lonidamine inhibition of the CFTR chloride channel.
Gong et al.
Lonidamine: in vitro/in vivo correlations.
Effects of lonidamine (AF 1890) and its analogues on follicle-stimulating hormone, luteinizing hormone, testost. and rat androgen binding protein concentrations in the rat and rhesus monkey.
Lobl et al.
Citation for Lonidamine
The citations listed below are publications that use Tocris products. Selected citations for Lonidamine include:
1 Citation: Showing 1 - 1
A mechanism for increased sensitivity of acute myeloid leukemia to mitotoxic drugs.
Authors: Panina Et al.
Cell Death Dis 2019;10:617
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