Anticancer and antispermatogenic agent in vitro
and in vivo
. Inhibits cellular energy metabolism in some cells via inhibition of mitochondrial hexokinase. Also blocks CFTR Cl-
channels in vitro
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All Tocris products are intended for laboratory research use only.
Effects of lonidamine on murine and human tumor cells in vitro. A morphological and biochemical study.
De Martino et al.
Mechanism of lonidamine inhibition of the CFTR chloride channel.
Gong et al.
Effects of lonidamine (AF 1890) and its analogues on follicle-stimulating hormone, luteinizing hormone, testosterone and rat androgen binding protein concentrations in the rat and rhesus monkey.
Lobl et al.
Lonidamine: in vitro/in vivo correlations.