Catalog Number: 1646
Alternate Names: AF 1890
Chemical Name: 1-[(2,4-Dichlorophenyl)methyl]-1H-indazole-3-carboxylic acid
Biological Activity
Anticancer and antispermatogenic agent in vitro and in vivo. Inhibits cellular energy metabolism in some cells via inhibition of mitochondrial hexokinase. Also blocks CFTR Cl- channels in vitro.
Technical Data
  • M.Wt:
    321.16
  • Formula:
    C15H10Cl2N2O2
  • Solubility:
    Soluble to 5 mM in ethanol and to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at RT
  • CAS No:
    50264-69-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Effects of lonidamine on murine and human tumor cells in vitro. A morphological and biochemical study.
    De Martino et al.
    Oncology, 1984;41:15
  2. Mechanism of lonidamine inhibition of the CFTR chloride channel.
    Gong et al.
    Br.J.Pharmacol., 2002;137:928
  3. Effects of lonidamine (AF 1890) and its analogues on follicle-stimulating hormone, luteinizing hormone, testosterone and rat androgen binding protein concentrations in the rat and rhesus monkey.
    Lobl et al.
    Chemotherapy, 1981;27:61
  4. Lonidamine: in vitro/in vivo correlations.
    Teiche
    Eur.J.Cancer, 1994;30A:1411

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