Loperamide hydrochloride

Catalog # Availability Size / Price Qty
Loperamide hydrochloride | CAS No. 34552-83-5 | mu Opioid Receptor Agonists
1 Image
Description: Peripherally acting μ agonist; Ca2+ channel blocker

Chemical Name: 4-(4-Chlorophenyl)-4-hydroxy-N,N-dimethyl-α,α-diphenyl-1-piperidinebutanamide hydrochloride

Purity: ≥99%

Product Details
Citations (1)
Supplemental Products

Biological Activity

Loperamide hydrochloride is a high affinity μ-opioid receptor agonist with peripheral selectivity (Ki values are 2, 48 and 1156 nM for μ-, δ- and κ-opioid receptors respectively). Antidiarrhoeal and antihyperalgesic agent. Also a Ca2+ channel blocker; at low micromolar concentrations it blocks broad spectrum neuronal HVA Ca2+ channels and at higher concentrations it reduces Ca2+ flux through NMDA receptor operated channels. Inhbits replication of MERS-CoV and SARS-CoV in vitro.

Technical Data

Soluble to 20 mM in ethanol and to 20 mM in DMSO
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Loperamide blocks high-voltage activated calcium channels and N-MthD.-aspartate -evoked responses in rat and mouse cultured hippocampal pyramidal neurons.
    Church et al.
    Mol.Pharmacol., 1994;45:747
  2. Loperamide (ADL 2-1294), an opioid antihyperalgesic agent with peripheral selectivity.
    Dehaven-Hudkins et al.
    J.Pharmacol.Exp.Ther., 1999;289:494
  3. Maitotoxin-elicited calcium influx in cultured cells - effect of calcium channel block.
    Daly et al.
    Biochem.Pharmacol., 1995;50:1187
  4. Pharmacology of antidiarrheal drugs.
    Awouters et al.
    Annu.Rev.Pharmacol.Toxicol., 1983;23:279
  5. Screening of an FDA-approved compound library identifies four small-molecule inhibitors of Middle East Respiratory Syndrome coronavirus replication in cell culture.
    de Wilde et al.
    Antimicrob.Agents.Chemother., 2014;58:4875

Product Datasheets

Or select another batch:
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Molarity Calculator


*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citation for Loperamide hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for Loperamide hydrochloride include:

1 Citation: Showing 1 - 1


No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for Loperamide hydrochloride

There are currently no reviews for this product. Be the first to review Loperamide hydrochloride and earn rewards!

Have you used Loperamide hydrochloride?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.