Catalog Number: 0840
Chemical Name: 4-(4-Chlorophenyl)-4-hydroxy-N,N-dimethyl-α,α-diphenyl-1-piperidinebutanamide hydrochloride
Biological Activity
High affinity μ-opioid receptor agonist with peripheral selectivity (Ki values are 2, 48 and 1156 nM for μ-, δ- and κ-opioid receptors respectively). Antidiarrhoeal and antihyperalgesic agent. Also a Ca2+ channel blocker; at low micromolar concentrations it blocks broad spectrum neuronal HVA Ca2+ channels and at higher concentrations it reduces Ca2+ flux through NMDA receptor operated channels.
Technical Data
  • M.Wt:
    513.51
  • Formula:
    C29H33ClN2O2.HCl
  • Solubility:
    Soluble to 20 mM in ethanol and to 20 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    34552-83-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Pharmacology of antidiarrheal drugs.
    Awouters et al.
    Annu.Rev.Pharmacol.Toxicol., 1983;23:279
  2. Loperamide (ADL 2-1294), an opioid antihyperalgesic agent with peripheral selectivity.
    Dehaven-Hudkins et al.
    J.Pharmacol.Exp.Ther., 1999;289:494
  3. Loperamide blocks high-voltage activated calcium channels and N-Methyl-D-aspartate -evoked responses in rat and mouse cultured hippocampal pyramidal neurons.
    Church et al.
    Mol.Pharmacol., 1994;45:747
  4. Maitotoxin-elicited calcium influx in cultured cells - effect of calcium channel block.
    Daly et al.
    Biochem.Pharmacol., 1995;50:1187
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Loperamide hydrochloride include:

1 Citations: Showing 1 - 1

  1. Calea zacatechichi dichloromethane extract exhibits antidiarrheal and antinociceptive effects in mouse models mimicking irritable bowel syndrome.
    Authors: Sałaga Et al.
    J Pharmacol Exp Ther 2015;388:1069

Have you used Loperamide hydrochloride?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details

Note:

Contact Information

Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee

or select another batch: 

Feedback

Customer Information