Lopinavir

Key Product Details

Product Description

Lopinavir is a highly potent and selective HIV-1 protease inhibitor (IC₅₀ = 6.5 nM, HIV cultured in peripheral blood mononuclear cells; K_i = 1.3 pM). Displays >10⁵-fold selectivity for HIV-1 protease over mammalian proteases including renin and cathepsin D and E. Inhibits HIV-1 protease in patient HIV isolates displaying mutations that confer resistance to ritonavir (Cat. No. 5856) (IC₅₀ values in 5 - 50 nM range). Also inhibits SARS-CoV-2 replication in vitro (IC₅₀ = 26 μM)

Product Specifications for Lopinavir

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Lopinavir

The following data is based on the product molecular weight 628.80.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.59 mL	7.95 mL	15.90 mL
5 mM	0.32 mL	1.59 mL	3.18 mL
10 mM	0.16 mL	0.80 mL	1.59 mL
50 mM	0.03 mL	0.16 mL	0.32 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Carrillo In vitro selection and characterization of human immunodeficiency virus type 1 variants with increased resistance to ABT-378, a novel protease inhibitor. J.Virol. 1998 PMID: 9696850
• Choy Remdesivir, lopinavir, emetine, and homoharringtonine inhibit SARS-CoV-2 replication in vitro. Antiviral Res. 2020 PMID: 32251767
• Sham ABT-378, a highly potent inhibitor of the human immunodeficiency virus protease. Antimicrob.Agents Chemother. 1998 PMID: 9835517

Product Documents for Lopinavir