Loratidine

Key Product Details

Product Description

Loratidine is a peripheral histamine H₁ receptor antagonist (K_i = 35 nM); devoid of central effects. Orally active antiallergic agent.

Product Specifications for Loratidine

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Loratidine

The following data is based on the product molecular weight 382.88.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.61 mL	13.06 mL	26.12 mL
5 mM	0.52 mL	2.61 mL	5.22 mL
10 mM	0.26 mL	1.31 mL	2.61 mL
50 mM	0.05 mL	0.26 mL	0.52 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 7 publications citing the usage of this product.

• Barnett Evaluation of the CNS properties of SCH 29851, a potential non-sedating antihistamine. Agents Actions 1984 PMID: 6236679
• Kreutner Antiallergic activity of loratidine, a non-sedating antihistamine. Allergy 1987 PMID: 2436504
• Ahn and Barnett Selective displacement of [³H]mepyramine from peripheral vs. central nervous system receptors by loratadine, a non-sedating antihistamine. Eur.J.Pharmacol. 1986 PMID: 2875889

Product Documents for Loratidine