Chemical Name: 4-(8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidinecarboxylic acid ethyl ester
Biological ActivityLoratidine is a peripheral histamine H1 receptor antagonist (Ki = 35 nM); devoid of central effects. Orally active antiallergic agent.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Selective displacement of [3H]mepyramine from peripheral vs. central nervous system receptors by loratadine, a non-sedating antihistamine.
Ahn and Barnett
Evaluation of the CNS properties of SCH 29851, a potential non-sedating antihistamine.
Barnett et al.
Agents Actions, 1984;14:590
Antiallergic activity of loratidine, a non-sedating antihistamine.
Kreutner et al.
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