Catalog Number: 1944
Alternate Names: SCH 29851
Chemical Name: 4-(8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidinecarboxylic acid ethyl ester
Biological Activity
Peripheral histamine H1 receptor antagonist (Ki = 35 nM); devoid of central effects. Orally active antiallergic agent.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 25 mM in DMSO and to 100 mM in ethanol
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Selective displacement of [3H]mepyramine from peripheral vs. central nervous system receptors by loratadine, a non-sedating antihistamine.
    Ahn and Barnett
    Eur.J.Pharmacol., 1986;127:153
  2. Evaluation of the CNS properties of SCH 29851, a potential non-sedating antihistamine.
    Barnett et al.
    Agents Actions, 1984;14:590
  3. Antiallergic activity of loratidine, a non-sedating antihistamine.
    Kreutner et al.
    Allergy, 1987;42:57
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