Chemical Name: 2-[(6-Chloro-7-cyclopropylthieno[3,2-d]pyrimidin-4-yl)thio]acetic acid
Biological ActivityNotum pectinacetylesterase inhibitor. Activates wnt signalling in vitro (EC50 values are 21 nM in human and 55 nM in mouse cell-based assay). Increases cortical bone thickness in mouse model of bone growth.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Stimulation of cortical bone formation with thienopyrimidine based inhibitors of Notum Pectinacetylesterase.
Tarver et al.
NOTUM inhibition increases endocortical bone formation and bone strength.
Brommage et al.
Bone Res., 2019;7
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